TNFRSF6B
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| Tumor necrosis factor receptor superfamily, member 6b, decoy | |||||||||||
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| Identifiers | |||||||||||
| Symbols | TNFRSF6B ; DCR3; DJ583P15.1.1; M68; TR6 | ||||||||||
| External IDs | Template:OMIM5 HomoloGene: 48242 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Tumor necrosis factor receptor superfamily, member 6b, decoy, also known as TNFRSF6B, is a human gene.[1]
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[1]
References
Further reading
- Pitti RM, Marsters SA, Lawrence DA; et al. (1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature. 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321.
- Yu KY, Kwon B, Ni J; et al. (1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J. Biol. Chem. 274 (20): 13733–6. PMID 10318773.
- Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.
- Bai C, Connolly B, Metzker ML; et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. PMID 10655513.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Migone TS, Zhang J, Luo X; et al. (2002). "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator". Immunity. 16 (3): 479–92. PMID 11911831.
- Hsu TL, Chang YC, Chen SJ; et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. PMID 11994433.
- Mild G, Bachmann F, Boulay JL; et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer". Int. J. Cancer. 102 (3): 254–7. doi:10.1002/ijc.10711. PMID 12397645.
- Gill RM, Ni J, Hunt JS (2003). "Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes". Am. J. Pathol. 161 (6): 2011–7. PMID 12466117.
- Wan X, Zhang J, Luo H; et al. (2003). "A TNF family member LIGHT transduces costimulatory signals into human T cells". J. Immunol. 169 (12): 6813–21. PMID 12471113.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Wan X, Shi G, Semenuk M; et al. (2003). "DcR3/TR6 modulates immune cell interactions". J. Cell. Biochem. 89 (3): 603–12. doi:10.1002/jcb.10523. PMID 12761893.
- Tsuji S, Hosotani R, Yonehara S; et al. (2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma". Int. J. Cancer. 106 (1): 17–25. doi:10.1002/ijc.11170. PMID 12794752.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Shi G, Wu Y, Zhang J, Wu J (2004). "Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo". J. Immunol. 171 (7): 3407–14. PMID 14500635.
- Wu SF, Liu TM, Lin YC; et al. (2004). "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication". J. Leukoc. Biol. 75 (2): 293–306. doi:10.1189/jlb.0303119. PMID 14634066.
- Chang YC, Hsu TL, Lin HH; et al. (2004). "Modulation of macrophage differentiation and activation by decoy receptor 3". J. Leukoc. Biol. 75 (3): 486–94. doi:10.1189/jlb.0903448. PMID 14657214.
- Kim S, McAuliffe WJ, Zaritskaya LS; et al. (2004). "Selective induction of tumor necrosis receptor factor 6/decoy receptor 3 release by bacterial antigens in human monocytes and myeloid dendritic cells". Infect. Immun. 72 (1): 89–93. PMID 14688085.
- Hsu MJ, Lin WW, Tsao WC; et al. (2004). "Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3". Exp. Cell Res. 292 (2): 241–51. PMID 14697332.
- Gill RM, Hunt JS (2004). "Soluble receptor (DcR3) and cellular inhibitor of apoptosis-2 (cIAP-2) protect human cytotrophoblast cells against LIGHT-mediated apoptosis". Am. J. Pathol. 165 (1): 309–17. PMID 15215185.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.