Sotalol detailed information
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| Sotalol detailed information
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| Systematic (IUPAC) name | |
| N-[4-(1-hydroxy-2-isopropylamino- ethyl)-phenyl]-methanesulfonamide | |
| Identifiers | |
| CAS number | |
| ATC code | C07 |
| PubChem | |
| Chemical data | |
| Formula | C12H20N2O3S |
| Mol. mass | 272.3624 g/mol |
| Pharmacokinetic data | |
| Bioavailability | >95% |
| Metabolism | Not metabolised |
| Half life | 12 hours |
| Excretion | Renal Lactic (In lactating females) |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status |
℞ Prescription only |
| Routes | oral |
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Sotalol (trade names Betapace and Betapace AF, Berlex Laboratories) is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals.
Pharmacology
It falls into the class III antiarrhythmic agents because it inhibits the inward potassium ion channels in the heart. It is also a beta blocker because of its primary action on the β-adrenergic receptors in the heart.
By blocking the potassium channels, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity.
It also slows atrioventricular (AV) nodal conduction (beta-blocking effect).
Sotalol is a racemic mix of D and L enantiomers. The L isomer is a beta blocker.
Sotalol is not selected for its beta-blocking ability, but rather for its Class III (potassium blocking) properties.
Indications
Sotalol is used to treat ventricular tachycardias as well as atrial fibrillation. Betapace AF is specifically labeled for atrial fibrillation.
Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to heart attack.[1]
Footnotes
See also
Beta blockers (C07) | |
|---|---|
| Non-selective β antagonists | Metipranolol • Nadolol • Oxprenolol • Penbutolol • Pindolol • Propranolol • Tertatolol • Timolol • Sotalol |
| β1 antagonists (cardioselective) | Atenolol • Acebutolol • Celiprolol • Betaxolol • Bisoprolol • Esmolol • Metoprolol • Nebivolol |
| Mixed α1/β antagonists | Carvedilol • Labetalol |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
