Rutin

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Rutin
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Disclaimer

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Rutin is a bioflavonoid that is FDA approved for the treatment of temporary relief of food and pollen sensitivities including rhinitis, sinusitis, nasal congestion, hay fever; impotence, lactose intolerance, and bladder infection.. Common adverse reactions include abdominal discomfort, palpitations, dizziness, headache, alopecia, tiredness, dry mouth, pruritus, leg edema, gastritis, vomiting, diarrhea, dyspepsia, skin rash, muscle stiffness.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Rutin in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Rutin in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Rutin in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Rutin in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Rutin in pediatric patients.

Contraindications

There is limited information regarding Rutin Contraindications in the drug label.

Warnings

  • Keep out of reach of children. In case of overdose, contact physician or Poison Control Center right away.
  • If pregnant or breast-feeding, seek advice of a health professional before use.
  • Tamper seal: "Sealed for Your Protection." Do not use if seal is broken or missing.


Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Rutin in the drug label.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Rutin in the drug label.

Drug Interactions

There is limited information regarding Rutin Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Rutin in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Rutin in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Rutin during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Rutin with respect to nursing mothers.

Pediatric Use

  • In case of overdose, contact physician or Poison Control Center right away.

Geriatic Use

There is no FDA guidance on the use of Rutin with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Rutin with respect to specific gender populations.

Race

There is no FDA guidance on the use of Rutin with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Rutin in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Rutin in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Rutin in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Rutin in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Rutin in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Rutin in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Rutin in the drug label.

Pharmacology

Rutin
Rutin structure.png
IUPAC name 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one
Other names Rutoside
Phytomelin
Sophorin
Birutan
Eldrin
Birutan Forte
Rutin trihydrate
Globularicitrin
Violaquercitrin
Identifiers
CAS number 153-18-4
PubChem 5280805
DrugBank DB01698
KEGG C05625
RTECS number VM2975000
ATC code C05CA01
InChI InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1
Properties
Molecular formula C27H30O16
Molar mass 610.52 g mol-1
Appearance Solid
Melting point

242 °C, 515 K, 468 °F

Solubility in water 12.5 mg/100 mL[1]
13 mg/100mL[2]
Hazards
NFPA 704

NFPA 704.svg

0
2
0
 
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Rutin Mechanism of Action in the drug label.

Structure

There is limited information regarding Rutin Structure in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Rutin in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Rutin in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Rutin in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Rutin in the drug label.

How Supplied

There is limited information regarding Rutin How Supplied in the drug label.

Storage

There is limited information regarding Rutin Storage in the drug label.

Images

Drug Images

Package and Label Display Panel

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Rutin in the drug label.

Precautions with Alcohol

  • Alcohol-Rutin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Rutin Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Rutin Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. Merck Index, 12th Edition, 8456
  2. Krewson, C. F.; Naghski, J. (2006). "Some physical properties of rutin". Journal of the American Pharmaceutical Association. 41 (11): 582–7. PMID 12999623. doi:10.1002/jps.3030411106. 

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