Reflux nephropathy
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Reflux nephropathy Classification and external resources | |
| ICD-9 | 593.73 |
|---|---|
| DiseasesDB | 11209 |
| MedlinePlus | 000459 |
| eMedicine | radio/597 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [3] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Reflux nephropathy, RN is a term applied when small and scarred kidneys (chronic pyelonephritis, CPN) are associated with vesico-ureteric reflux (VUR). CPN being the commonest cause, there are other causes including analgesic nephropathy and obstructive injury. Scarring is essential in developing RN and occurs almost during the first five years of life. The end results of RN are hypertension, proteinuria, CRF and eventually ESRD, end stage renal disease.
Diagnosis
It is diagnosed by micturating cystography, scarring can of course be demonstrated by ultrasound or DMSA.
Incidence/prevalence
There is a genetic predisposition, first-degree relatives have a great increase in the chance of VUR.
The gene frequency is estimated to be 1:600. All children with UTI should be investigated for VUR.
Treatment
The aim of treatment is to reduce renal scarring. Those children with grade II or worse should receive low dose prophylactic antibiotics (Nitrofurantoin, trimethoprim, co-trimoxazole, cefalexin in those with CRF). Hypertension should be managed with ACE inhibitors or ARB's. Other treatment modalities also include surgery (endoscopic injection of collagen behind the intra-vesical ureter, ureteric re-implantation or lengthening of the submucosal ureteric tunnel) which has its protagonists.
WikiDoc Research Resources for Reflux nephropathy | |
|---|---|
| Articles on Reflux nephropathy | Most recent articles on Reflux nephropathy • Most cited articles on Reflux nephropathy • Review articles on Reflux nephropathy • Articles on Reflux nephropathy in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Reflux nephropathy | Powerpoint slides on Reflux nephropathy • Images of Reflux nephropathy • Photos of Reflux nephropathy • Podcasts & MP3s on Reflux nephropathy • Videos on Reflux nephropathy |
| Evidence Based Medicine Regarding Reflux nephropathy | Cochrane Collaboration on Reflux nephropathy • Bandolier on Reflux nephropathy • TRIP on Reflux nephropathy |
| Cost Effectiveness of Reflux nephropathy | Cost Effectiveness of Reflux nephropathy |
| Clinical Trials Involving Reflux nephropathy | Ongoing Trials on Reflux nephropathy at Clinical Trials.gov • Trial results on Reflux nephropathy • Clinical Trials on Reflux nephropathy at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Reflux nephropathy | US National Guidelines Clearinghouse on Reflux nephropathy • NICE Guidance on Reflux nephropathy • NHS PRODIGY Guidance • FDA on Reflux nephropathy • CDC on Reflux nephropathy |
| Textbook Information on Reflux nephropathy | Books and Textbook Information on Reflux nephropathy |
| Pharmacology Resources on Reflux nephropathy | Dosing of Reflux nephropathy • Drug interactions with Reflux nephropathy • Side effects of Reflux nephropathy • Allergic reactions to Reflux nephropathy • Overdose information on Reflux nephropathy • Carcinogenicity information on Reflux nephropathy • Reflux nephropathy in pregnancy • Pharmacokinetics of Reflux nephropathy • |
| Genetics, Pharmacogenomics, and Proteinomics of Reflux nephropathy | Genetics of Reflux nephropathy • Pharmacogenomics of Reflux nephropathy • Proteomics of Reflux nephropathy |
| Newstories on Reflux nephropathy | Reflux nephropathy in the news • Be alerted to news on Reflux nephropathy • News trends on Reflux nephropathy |
| Commentary on Reflux nephropathy | Blogs on Reflux nephropathy |
| Patient Resources on Reflux nephropathy | Patient resources on Reflux nephropathy • Discussion groups on Reflux nephropathy • Patient Handouts on Reflux nephropathy • Directions to Hospitals Treating Reflux nephropathy • Risk calculators and risk factors for Reflux nephropathy |
| Healthcare Provider Resources on Reflux nephropathy | Symptoms of Reflux nephropathy • Causes & Risk Factors for Reflux nephropathy • Diagnostic studies for Reflux nephropathy • Treatment of Reflux nephropathy |
| Continuing Medical Education (CME) Programs on Reflux nephropathy | CME Programs on Reflux nephropathy |
| International Resources on Reflux nephropathy | Reflux nephropathy en Espanol • Reflux nephropathy en Francais |
| Business Resources on Reflux nephropathy | Reflux nephropathy in the Marketplace • Patents on Reflux nephropathy |
| Informatics Resources on Reflux nephropathy | List of terms related to Reflux nephropathy |
| ||||
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
