RANTES
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| The structure of human RANTES | |
| chemokine (C-C motif) ligand 5
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| Identifiers | |
| Symbol | CCL5 |
| Alt. Symbols | D17S136E, SCYA5 |
| Entrez | 6352 |
| HUGO | 10632 |
| OMIM | 187011 |
| PDB | 1PMI |
| RefSeq | NM_002985 |
| UniProt | P13501 |
| Other data | |
| Locus | Chr. 17 q11.2-q12 |
Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-γ) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.[1] It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.[2]
References
- ↑ Maghazachi et al, CC chemokines induce the generation of killer cells from CD56+ cells, Eur J Immunol. 1996, 26:315-9.
- ↑ Donlon et al. Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12. Genomics 5: 548-553, 1990.
See also
Cytokines: chemokines | |
|---|---|
| CCL | CCL1 - CCL2 - CCL3 - CCL4 - CCL5 - CCL6 - CCL7 - CCL8 - CCL9 - CCL10 - CCL11 - CCL12 - CCL13 - CCL14 - CCL15 - CCL16 - CCL17 - CCL18 - CCL19 - CCL20 - CCL21 - CCL22 - CCL23 - CCL24 - CCL25 - CCL26 - CCL27 - CCL28 |
| CXCL | CXCL1 - CXCL2 - CXCL3 - CXCL4 - CXCL5 - CXCL6 - CXCL7 - CXCL8 - CXCL9 - CXCL10 - CXCL11 - CXCL12 - CXCL13 - CXCL14 - CXCL15 - CXCL16 - CXCL17 |
| CX3CL | CX3CL1 |
| XCL | XCL1 - XCL2 |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
