Pyoderma gangrenosum

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Overview

Pyoderma gangrenosum
Pyoderma gangrenosum.jpg
Pyoderma gangrenosum: Gros; Leg
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10 L88.
ICD-9 686.01

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Pyoderma gangrenosum

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Pyoderma gangrenosum is a disease that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds. Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers. Though the wounds rarely lead to death, they can cause pain and scarring.

The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.[1]

Types

There are two main types of pyoderma gangrenosum:[1]

  • the normal ulcerative form, which occurs in the legs
  • an 'atypical' form that is more superficial and occurs in the hands and other parts of the body

Other variations are[2]:

  • Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma
  • Bullous pyoderma gangrenosum
  • Pustular pyoderma gangrenosum[3]
  • Vegetative pyoderma gangrenosum[4]

Diagnosis

Common Causes

Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function.[1] For instance, ulcerative colitis, Crohn's disease,rheumatoid arthritis, myeloma sufferers have the condition.

Physical Examination

Extremities

Associations

The common conditions associated with pyoderma gangrenosum are:

  • Inflammatory bowel disease:
  • Chronic ulcerative colitis
  • Crohn's disease
  • Arthritides:
  • Rheumatoid arthritis
  • Seronegative symmetrical polyarthritis
  • Hematological disease:
  • Myelocytic leukaemia
  • Hairy cell leukaemia
  • Myelofibrosis
  • Myeloid metaplasia
  • Monoclonal gammopathy (IgA) [5]

Treatment

A number of treatment options exist.[6]

References

  1. 1.0 1.1 1.2 Jackson JM and Callen JP. 2006. Emedicine: Pyoderma Gangrenosum. Retrieved on January 23, 2007.
  2. Brooklyn T, Dunnill G, Probert C (2006). "Diagnosis and treatment of pyoderma gangrenosum". BMJ 333 (7560): 181-4. doi:10.1136/bmj.333.7560.181. PMID 16858047.
  3. Shankar S, Sterling JC, Rytina E (2003). "Pustular pyoderma gangrenosum". Clin. Exp. Dermatol. 28 (6): 600-3. doi:10.1046/j.1365-2230.2003.01418.x. PMID 14616824.
  4. Langan SM, Powell FC (2005). "Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature". Int. J. Dermatol. 44 (8): 623-9. doi:10.1111/j.1365-4632.2005.02591.x. PMID 16101860.
  5. http://www.gpnotebook.com/simplepage.cfm?ID=-771358647&linkID=28508&cook=no
  6. Reichrath J, Bens G, Bonowitz A, Tilgen W (2005). "Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients". J. Am. Acad. Dermatol. 53 (2): 273-83. doi:10.1016/j.jaad.2004.10.006. PMID 16021123.

External links

  • Erythema Nodosum Online Support Group for those with Pyoderma Gangrenosum [3]
Cost Effectiveness of Pyoderma gangrenosum

| group5 = Clinical Trials Involving Pyoderma gangrenosum | list5 = Ongoing Trials on Pyoderma gangrenosum at Clinical Trials.govTrial results on Pyoderma gangrenosumClinical Trials on Pyoderma gangrenosum at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pyoderma gangrenosum | list6 = US National Guidelines Clearinghouse on Pyoderma gangrenosumNICE Guidance on Pyoderma gangrenosumNHS PRODIGY GuidanceFDA on Pyoderma gangrenosumCDC on Pyoderma gangrenosum


| group7 = Textbook Information on Pyoderma gangrenosum | list7 = Books and Textbook Information on Pyoderma gangrenosum


| group8 = Pharmacology Resources on Pyoderma gangrenosum | list8 = AND (Dose)}} Dosing of Pyoderma gangrenosumAND (drug interactions)}} Drug interactions with Pyoderma gangrenosumAND (side effects)}} Side effects of Pyoderma gangrenosumAND (Allergy)}} Allergic reactions to Pyoderma gangrenosumAND (overdose)}} Overdose information on Pyoderma gangrenosumAND (carcinogenicity)}} Carcinogenicity information on Pyoderma gangrenosumAND (pregnancy)}} Pyoderma gangrenosum in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Pyoderma gangrenosum


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Pyoderma gangrenosum | list9 = AND (pharmacogenomics)}} Genetics of Pyoderma gangrenosumAND (pharmacogenomics)}} Pharmacogenomics of Pyoderma gangrenosumAND (proteomics)}} Proteomics of Pyoderma gangrenosum


| group10 = Newstories on Pyoderma gangrenosum | list10 = Pyoderma gangrenosum in the newsBe alerted to news on Pyoderma gangrenosumNews trends on Pyoderma gangrenosum</small>


| group11 = Commentary on Pyoderma gangrenosum | list11 = Blogs on Pyoderma gangrenosum

| group12 = Patient Resources on Pyoderma gangrenosum | list12 = Patient resources on Pyoderma gangrenosumDiscussion groups on Pyoderma gangrenosumPatient Handouts on Pyoderma gangrenosumDirections to Hospitals Treating Pyoderma gangrenosumRisk calculators and risk factors for Pyoderma gangrenosum


| group13 = Healthcare Provider Resources on Pyoderma gangrenosum | list13 = Symptoms of Pyoderma gangrenosumCauses & Risk Factors for Pyoderma gangrenosumDiagnostic studies for Pyoderma gangrenosumTreatment of Pyoderma gangrenosum

| group14 = Continuing Medical Education (CME) Programs on Pyoderma gangrenosum | list14 = CME Programs on Pyoderma gangrenosum

| group15 = International Resources on Pyoderma gangrenosum | list15 = Pyoderma gangrenosum en EspanolPyoderma gangrenosum en Francais

| group16 = Business Resources on Pyoderma gangrenosum | list16 = Pyoderma gangrenosum in the MarketplacePatents on Pyoderma gangrenosum

| group17 = Informatics Resources on Pyoderma gangrenosum | list17 = List of terms related to Pyoderma gangrenosum


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