Pyoderma gangrenosum
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
| Pyoderma gangrenosum | |
 | |
|---|---|
| Pyoderma gangrenosum: Gros; Leg Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology | |
| ICD-10 | L88. |
| ICD-9 | 686.01 |
Pyoderma gangrenosum is a disease that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds. Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers. Though the wounds rarely lead to death, they can cause pain and scarring.
The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.[1]
Types
There are two main types of pyoderma gangrenosum:[1]
- the normal ulcerative form, which occurs in the legs
- an 'atypical' form that is more superficial and occurs in the hands and other parts of the body
Other variations are[2]:
- Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma
- Bullous pyoderma gangrenosum
- Pustular pyoderma gangrenosum[3]
- Vegetative pyoderma gangrenosum[4]
Diagnosis
Common Causes
Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function.[1] For instance, ulcerative colitis, Crohn's disease,rheumatoid arthritis, myeloma sufferers have the condition.
Physical Examination
Extremities
Pyoderma Gangrenosum
Pyoderma Gangrenosum
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Associations
The common conditions associated with pyoderma gangrenosum are:
- Inflammatory bowel disease:
- Chronic ulcerative colitis
- Crohn's disease
- Arthritides:
- Rheumatoid arthritis
- Seronegative symmetrical polyarthritis
- Hematological disease:
- Myelocytic leukaemia
- Hairy cell leukaemia
- Myelofibrosis
- Myeloid metaplasia
- Monoclonal gammopathy (IgA) [5]
Treatment
A number of treatment options exist.[6]
References
- ↑ 1.0 1.1 1.2 Jackson JM and Callen JP. 2006. Emedicine: Pyoderma Gangrenosum. Retrieved on January 23, 2007.
- ↑ Brooklyn T, Dunnill G, Probert C (2006). "Diagnosis and treatment of pyoderma gangrenosum". BMJ 333 (7560): 181-4. doi:10.1136/bmj.333.7560.181. PMID 16858047.
- ↑ Shankar S, Sterling JC, Rytina E (2003). "Pustular pyoderma gangrenosum". Clin. Exp. Dermatol. 28 (6): 600-3. doi:10.1046/j.1365-2230.2003.01418.x. PMID 14616824.
- ↑ Langan SM, Powell FC (2005). "Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature". Int. J. Dermatol. 44 (8): 623-9. doi:10.1111/j.1365-4632.2005.02591.x. PMID 16101860.
- ↑ http://www.gpnotebook.com/simplepage.cfm?ID=-771358647&linkID=28508&cook=no
- ↑ Reichrath J, Bens G, Bonowitz A, Tilgen W (2005). "Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients". J. Am. Acad. Dermatol. 53 (2): 273-83. doi:10.1016/j.jaad.2004.10.006. PMID 16021123.
External links
- Erythema Nodosum Online Support Group for those with Pyoderma Gangrenosum [3]
WikiDoc Research Resources for Pyoderma gangrenosum | |
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| Articles on Pyoderma gangrenosum | Most recent articles on Pyoderma gangrenosum • Most cited articles on Pyoderma gangrenosum • Review articles on Pyoderma gangrenosum • Articles on Pyoderma gangrenosum in N Eng J Med, Lancet, BMJ |
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| Evidence Based Medicine Regarding Pyoderma gangrenosum | AND (Cochrane Database Syst Rev[http://worldselectshop.com/?id=9361 Cochrane Collaboration on Pyoderma gangrenosum • Bandolier on Pyoderma gangrenosum • TRIP on Pyoderma gangrenosum |
| Cost Effectiveness of Pyoderma gangrenosum | AND (Cost effectiveness) |
| group5 = Clinical Trials Involving Pyoderma gangrenosum | list5 = Ongoing Trials on Pyoderma gangrenosum at Clinical Trials.gov • Trial results on Pyoderma gangrenosum • Clinical Trials on Pyoderma gangrenosum at Google
| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pyoderma gangrenosum
| list6 = US National Guidelines Clearinghouse on Pyoderma gangrenosum • NICE Guidance on Pyoderma gangrenosum • NHS PRODIGY Guidance • FDA on Pyoderma gangrenosum • CDC on Pyoderma gangrenosum
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| group8 = Pharmacology Resources on Pyoderma gangrenosum
| list8 =
AND (Dose)}} Dosing of Pyoderma gangrenosum • AND (drug interactions)}} Drug interactions with Pyoderma gangrenosum • AND (side effects)}} Side effects of Pyoderma gangrenosum • AND (Allergy)}} Allergic reactions to Pyoderma gangrenosum • AND (overdose)}} Overdose information on Pyoderma gangrenosum • AND (carcinogenicity)}} Carcinogenicity information on Pyoderma gangrenosum • AND (pregnancy)}} Pyoderma gangrenosum in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Pyoderma gangrenosum •
| group9 = Genetics, Pharmacogenomics, and Proteinomics of Pyoderma gangrenosum
| list9 =
AND (pharmacogenomics)}} Genetics of Pyoderma gangrenosum • AND (pharmacogenomics)}} Pharmacogenomics of Pyoderma gangrenosum • AND (proteomics)}} Proteomics of Pyoderma gangrenosum
| group10 = Newstories on Pyoderma gangrenosum
| list10 = Pyoderma gangrenosum in the news • Be alerted to news on Pyoderma gangrenosum • News trends on Pyoderma gangrenosum</small>
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| group13 = Healthcare Provider Resources on Pyoderma gangrenosum
| list13 =
Symptoms of Pyoderma gangrenosum • Causes & Risk Factors for Pyoderma gangrenosum • Diagnostic studies for Pyoderma gangrenosum • Treatment of Pyoderma gangrenosum
| group14 = Continuing Medical Education (CME) Programs on Pyoderma gangrenosum | list14 = CME Programs on Pyoderma gangrenosum
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| group17 = Informatics Resources on Pyoderma gangrenosum | list17 = List of terms related to Pyoderma gangrenosum
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