Prostaglandin-F synthase

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In enzymology, a prostaglandin-F synthase (EC 1.1.1.188) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP⁺ (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate and NADP⁺, whereas its 3 products are (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP + 11-oxidoreductase. Other names in common use include prostaglandin-D2 11-reductase, reductase, 15-hydroxy-11-oxoprostaglandin, PGD2 11-ketoreductase, PGF2alpha synthetase, prostaglandin 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthetase, synthetase, prostaglandin F2alpha, prostaglandin-D2 11-reductase, PGF synthetase, NADPH-dependent prostaglandin D2 11-keto reductase, and prostaglandin 11-keto reductase. This enzyme participates in arachidonic acid metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1VBJ, 1XF0, 1ZQ5, 2F38, and 2FGB.

References

• IUBMB entry for 1.1.1.188
• BRENDA references for 1.1.1.188 (Recommended.)
• PubMed references for 1.1.1.188
• PubMed Central references for 1.1.1.188
• Google Scholar references for 1.1.1.188
• Reingold DF, Kawasaki A, Needleman P (1981). "A novel prostaglandin 11-keto reductase found in rabbit liver". Biochim. Biophys. Acta. 659: 179–88. PMID 7248318.
• Watanabe K, Shimizu T and Hayaishi O (1981). "Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung". Biochem. Int. 2: 603–610.
• Watanabe K, Yoshida R, Shimizu T, Hayaishi O (1985). "Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung". J. Biol. Chem. 260: 7035–41. PMID 3858278.
• Wong PY (1981). "Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver". Biochim. Biophys. Acta. 659: 169–78. PMID 7248317.
• Wong PY (1982). "Purification of PGD2 11-ketoreductase from rabbit liver". Methods. Enzymol. 86: 117–25. PMID 7132748.

External links

The CAS registry number for this enzyme class is 55976-95-9.

• IUBMB entry for 1.1.1.188

• KEGG entry for 1.1.1.188

• BRENDA entry for 1.1.1.188

• NiceZyme view of 1.1.1.188

• EC2PDB: PDB structures for 1.1.1.188

• PRIAM entry for 1.1.1.188

• PUMA2 entry for 1.1.1.188

• IntEnz: Integrated Enzyme entry for 1.1.1.188

• MetaCyc entry for 1.1.1.188

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047017: prostaglandin-F synthase

• AMIGO entry for GO code 0047017: prostaglandin-F synthase

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