Proguanil
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| Image:Proguanil.svg | |
| Proguanil
| |
| Systematic (IUPAC) name | |
| 1-(4-chlorophenyl)-2-(N'-propan-2-ylcarbamimidoyl) guanidine | |
| Identifiers | |
| CAS number | |
| ATC code | P01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C11H16ClN5 |
| Mol. mass | 253.731 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ~20 h |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Proguanil (proguanil hydrochloride) is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Proguanil is effective against sporozoites.
Proguanil is usually taken in combination with another anti-malarial drug such as atovaquone (e.g., in the drug Malarone) or chloroquine. Malarone has fewer side effects than mefloquine, but can be more expensive because it's taken daily. Proguanil is taken with Atovaquone for chloroquine-resistant and multidrug resistant strains of P. falciparum and P. vivax.
Proguanil also known as Paludrine (Astra Zeneca)
References
Antiprotozoals: Antimalarial drugs (P01B) | |
|---|---|
| Aminoquinolines | 4-Aminoquinoline (Amodiaquine, Chloroquine, Hydroxychloroquine) • 8-Aminoquinoline (Pamaquine, Primaquine) |
| Methanolquinolines | Mefloquine • Quinine |
| Biguanides | Proguanil • Cycloguanil embolate |
| Diaminopyridines | Pyrimethamine |
| Artemisinin derivatives | Artemisinin • Artemether • Artesunate • Artenimol • Arteether/Artemotil |
| Others | Halofantrine • Lumefantrine |
 | This antimicrobial-related article is a stub. You can help Wikipedia by expanding it. |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
