Progestagen

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Progestagens (also spelled progestogens or gestagens) are hormones which produce effects similar to progesterone, the only natural progestagen. All other progestogens are synthetic and are often referred to as progestins.

All progestagens have antiestrogenic (counteracting the effects of estrogens on the body) and antigonadotropic (inhibiting the production of sex steroids by gonads) properties.

Progestogens differ in their potency (affinity for progesterone receptors) and side effects. Such side effects may be androgenic (medroxyprogesterone and most C19 progestagens), antiandrogenic (cyproterone acetate), estrogenic, glucocorticoid (some C21 progestogens) or antimineralocorticoid (progesterone).

Uses

Birth control

• • Progestogens are used alone in progestogen only pills, or with an estrogen in combined oral contraceptive pills, a contraceptive patch, and a contraceptive vaginal ring.
  • Medroxyprogesterone acetate (Depo-Provera) and norethindrone enantate (Noristerat) are used by depot injection.
  • Etonogestrol is released by subcutaneous implants (Implanon). Norplant and Jadelle implants release levonorgestrel.
  • Levonorgestrel is released by the intrauterine system IUS (Mirena).

Antiandrogen

Cyproterone is an antiandrogen.

Progestogen withdrawal bleeding

In a normal menstrual cycle, a sudden drop in progesterone levels triggers menstruation. Norethindrone acetate (brand name Aygestin) and medroxyprogesterone acetate (brand name Provera) may be used to artificially induce progestogen withdrawal bleeding.

External links

• The Million Women Study
• The Women's HOPE Study (PubMed Abstract)
• HERS Study (JAMA Abstract)

Cost Effectiveness of Progestagen

| group5 = Clinical Trials Involving Progestagen | list5 = Ongoing Trials on Progestagen at Clinical Trials.gov • Trial results on Progestagen • Clinical Trials on Progestagen at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Progestagen | list6 = US National Guidelines Clearinghouse on Progestagen • NICE Guidance on Progestagen • NHS PRODIGY Guidance • FDA on Progestagen • CDC on Progestagen

| group7 = Textbook Information on Progestagen | list7 = Books and Textbook Information on Progestagen

| group8 = Pharmacology Resources on Progestagen | list8 = AND (Dose)}} Dosing of Progestagen • AND (drug interactions)}} Drug interactions with Progestagen • AND (side effects)}} Side effects of Progestagen • AND (Allergy)}} Allergic reactions to Progestagen • AND (overdose)}} Overdose information on Progestagen • AND (carcinogenicity)}} Carcinogenicity information on Progestagen • AND (pregnancy)}} Progestagen in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Progestagen •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Progestagen | list9 = AND (pharmacogenomics)}} Genetics of Progestagen • AND (pharmacogenomics)}} Pharmacogenomics of Progestagen • AND (proteomics)}} Proteomics of Progestagen

| group10 = Newstories on Progestagen | list10 = Progestagen in the news • Be alerted to news on Progestagen • News trends on Progestagen</small>

| group11 = Commentary on Progestagen | list11 = Blogs on Progestagen

| group12 = Patient Resources on Progestagen | list12 = Patient resources on Progestagen • Discussion groups on Progestagen • Patient Handouts on Progestagen • Directions to Hospitals Treating Progestagen • Risk calculators and risk factors for Progestagen

| group13 = Healthcare Provider Resources on Progestagen | list13 = Symptoms of Progestagen • Causes & Risk Factors for Progestagen • Diagnostic studies for Progestagen • Treatment of Progestagen

| group14 = Continuing Medical Education (CME) Programs on Progestagen | list14 = CME Programs on Progestagen

| group15 = International Resources on Progestagen | list15 = Progestagen en Espanol • Progestagen en Francais

| group16 = Business Resources on Progestagen | list16 = Progestagen in the Marketplace • Patents on Progestagen

| group17 = Informatics Resources on Progestagen | list17 = List of terms related to Progestagen

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