Primitive neuroectodermal tumor

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Overview

Primitive Neuroectodermal Tumors, or PNET, refers to two different tumor types. These include Peripheral PNET and CNS PNET. This can be a source of confusion.

Some PNET Types

Peripheral PNET

The Peripheral PNET is now thought to be virually identical to Ewing sarcoma:

"Current evidence indicates that both Ewing's sarcoma and PNET have a similar neural phenotype and, because they share an identical chromosome translocation, they should be viewed as the same tumor, differing only in their degree of neural differentiation. Tumors that demonstrate neural differentiation by light microscopy, immunohistochemistry, or electron microscopy have been traditionally labeled PNETs, and those that are undifferentiated by these analyses have been diagnosed as Ewing's sarcoma." ^[1]

PNET of the CNS

PNET of the CNS are grossly divided into supratentorial PNET and infratentorial PNET, the latter being more common. ^[1]

An example of infratentorial PNET includes Medulloblastomas, which occurs in the cerebellum.

An example of supratentorial PNET includes Pinealoblastomas, which occurs in the pineal region.

References

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Initial content for this page in some instances came from Wikipedia

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v • d • e WikiDoc Research Resources for Primitive neuroectodermal tumor
Articles on Primitive neuroectodermal tumor	Most recent articles on Primitive neuroectodermal tumor • Most cited articles on Primitive neuroectodermal tumor • Review articles on Primitive neuroectodermal tumor • Articles on Primitive neuroectodermal tumor in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Primitive neuroectodermal tumor	Powerpoint slides on Primitive neuroectodermal tumor • Images of Primitive neuroectodermal tumor • Photos of Primitive neuroectodermal tumor • Podcasts & MP3s on Primitive neuroectodermal tumor • Videos on Primitive neuroectodermal tumor
Evidence Based Medicine Regarding Primitive neuroectodermal tumor	Cochrane Collaboration on Primitive neuroectodermal tumor • Bandolier on Primitive neuroectodermal tumor • TRIP on Primitive neuroectodermal tumor
Cost Effectiveness of Primitive neuroectodermal tumor	Cost Effectiveness of Primitive neuroectodermal tumor
Clinical Trials Involving Primitive neuroectodermal tumor	Ongoing Trials on Primitive neuroectodermal tumor at Clinical Trials.gov • Trial results on Primitive neuroectodermal tumor • Clinical Trials on Primitive neuroectodermal tumor at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Primitive neuroectodermal tumor	US National Guidelines Clearinghouse on Primitive neuroectodermal tumor • NICE Guidance on Primitive neuroectodermal tumor • NHS PRODIGY Guidance • FDA on Primitive neuroectodermal tumor • CDC on Primitive neuroectodermal tumor
Textbook Information on Primitive neuroectodermal tumor	Books and Textbook Information on Primitive neuroectodermal tumor
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Genetics, Pharmacogenomics, and Proteinomics of Primitive neuroectodermal tumor	Genetics of Primitive neuroectodermal tumor • Pharmacogenomics of Primitive neuroectodermal tumor • Proteomics of Primitive neuroectodermal tumor
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Commentary on Primitive neuroectodermal tumor	Blogs on Primitive neuroectodermal tumor
Patient Resources on Primitive neuroectodermal tumor	Patient resources on Primitive neuroectodermal tumor • Discussion groups on Primitive neuroectodermal tumor • Patient Handouts on Primitive neuroectodermal tumor • Directions to Hospitals Treating Primitive neuroectodermal tumor • Risk calculators and risk factors for Primitive neuroectodermal tumor
Healthcare Provider Resources on Primitive neuroectodermal tumor	Symptoms of Primitive neuroectodermal tumor • Causes & Risk Factors for Primitive neuroectodermal tumor • Diagnostic studies for Primitive neuroectodermal tumor • Treatment of Primitive neuroectodermal tumor
Continuing Medical Education (CME) Programs on Primitive neuroectodermal tumor	CME Programs on Primitive neuroectodermal tumor
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