Polycythemia causes

Jump to navigation Jump to search

Polycythemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Polycythemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography or Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Polycythemia causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Polycythemia causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Polycythemia causes

CDC on Polycythemia causes

Polycythemia causes in the news

Blogs on Polycythemia causes

Directions to Hospitals Treating Polycythemia

Risk calculators and risk factors for Polycythemia causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

Divided into primary and secondary causes based on underlying genetic mutations and other factors(refer to classification).

Causes

Common Causes

Common causes of polycythemia may include:

Polycythemia vera

Congenital

Acquired

Pathologic EPO production:[10]

Exogenous EPO:

Idiopathic erythrocytosis [12][13] [14]

References

  1. McMullin MF (2012). "Diagnosis and management of congenital and idiopathic erythrocytosis". Ther Adv Hematol. 3 (6): 391–8. doi:10.1177/2040620712458947. PMC 3627324. PMID 23606940.
  2. Johansson PL, Safai-Kutti S, Kutti J (2005). "An elevated venous haemoglobin concentration cannot be used as a surrogate marker for absolute erythrocytosis: a study of patients with polycythaemia vera and apparent polycythaemia". Br J Haematol. 129 (5): 701–5. doi:10.1111/j.1365-2141.2005.05517.x. PMID 15916693.
  3. Percy MJ, Butt NN, Crotty GM, Drummond MW, Harrison C, Jones GL; et al. (2009). "Identification of high oxygen affinity hemoglobin variants in the investigation of patients with erythrocytosis". Haematologica. 94 (9): 1321–2. doi:10.3324/haematol.2009.008037. PMC 2738729. PMID 19734427.
  4. Rosa R, Prehu MO, Beuzard Y, Rosa J (1978). "The first case of a complete deficiency of diphosphoglycerate mutase in human erythrocytes". J Clin Invest. 62 (5): 907–15. doi:10.1172/JCI109218. PMC 371847. PMID 152321.
  5. Gordeuk VR, Prchal JT (2006). "Vascular complications in Chuvash polycythemia". Semin Thromb Hemost. 32 (3): 289–94. doi:10.1055/s-2006-939441. PMID 16673284.
  6. Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y; et al. (2002). "Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia". Nat Genet. 32 (4): 614–21. doi:10.1038/ng1019. PMID 12415268.
  7. Gordeuk VR, Sergueeva AI, Miasnikova GY, Okhotin D, Voloshin Y, Choyke PL; et al. (2004). "Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors". Blood. 103 (10): 3924–32. doi:10.1182/blood-2003-07-2535. PMID 14726398.
  8. McMullin MF (2010). "HIF pathway mutations and erythrocytosis". Expert Rev Hematol. 3 (1): 93–101. doi:10.1586/ehm.09.68. PMID 21082936.
  9. Percy MJ, Furlow PW, Lucas GS, Li X, Lappin TR, McMullin MF; et al. (2008). "A gain-of-function mutation in the HIF2A gene in familial erythrocytosis". N Engl J Med. 358 (2): 162–8. doi:10.1056/NEJMoa073123. PMC 2295209. PMID 18184961.
  10. Jelkmann W, Lundby C (2011). "Blood doping and its detection". Blood. 118 (9): 2395–404. doi:10.1182/blood-2011-02-303271. PMID 21652677.
  11. Dickerman RD, Pertusi R, Miller J, Zachariah NY (1999). "Androgen-induced erythrocytosis: is it erythropoietin?". Am J Hematol. 61 (2): 154–5. doi:10.1002/(sici)1096-8652(199906)61:2<154::aid-ajh17>3.0.co;2-s. PMID 10367800.
  12. Percy MJ (2007). "Genetically heterogeneous origins of idiopathic erythrocytosis". Hematology. 12 (2): 131–9. doi:10.1080/10245330601111979. PMID 17454194.
  13. McMULLIN, M. F. (2008). "The classification and diagnosis of erythrocytosis". International Journal of Laboratory Hematology. doi:10.1111/j.1751-553X.2008.01102.x. ISSN 1751-5521.
  14. Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L (October 1976). "Polycythemia vera: stem-cell and probable clonal origin of the disease". N Engl J Med. 295 (17): 913–6. doi:10.1056/NEJM197610212951702. PMID 967201.

Template:WS Template:WH