Pinacidil

Jump to: navigation, search
Pinacidil
Pinacidil.png
IUPAC name 3-cyano-1-(4-pyridyl)-2-(1,2,2-trimethylpropyl)guanidine
Identifiers
CAS number 85371-64-8
PubChem 4826
SMILES CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
Properties
Molecular formula C13H19N5
Molar mass 245.32346
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

WikiDoc Resources for

Pinacidil

Articles

Most recent articles on Pinacidil

Most cited articles on Pinacidil

Review articles on Pinacidil

Articles on Pinacidil in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Pinacidil

Images of Pinacidil

Photos of Pinacidil

Podcasts & MP3s on Pinacidil

Videos on Pinacidil

Evidence Based Medicine

Cochrane Collaboration on Pinacidil

Bandolier on Pinacidil

TRIP on Pinacidil

Clinical Trials

Ongoing Trials on Pinacidil at Clinical Trials.gov

Trial results on Pinacidil

Clinical Trials on Pinacidil at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Pinacidil

NICE Guidance on Pinacidil

NHS PRODIGY Guidance

FDA on Pinacidil

CDC on Pinacidil

Books

Books on Pinacidil

News

Pinacidil in the news

Be alerted to news on Pinacidil

News trends on Pinacidil

Commentary

Blogs on Pinacidil

Definitions

Definitions of Pinacidil

Patient Resources / Community

Patient resources on Pinacidil

Discussion groups on Pinacidil

Patient Handouts on Pinacidil

Directions to Hospitals Treating Pinacidil

Risk calculators and risk factors for Pinacidil

Healthcare Provider Resources

Symptoms of Pinacidil

Causes & Risk Factors for Pinacidil

Diagnostic studies for Pinacidil

Treatment of Pinacidil

Continuing Medical Education (CME)

CME Programs on Pinacidil

International

Pinacidil en Espanol

Pinacidil en Francais

Business

Pinacidil in the Marketplace

Patents on Pinacidil

Experimental / Informatics

List of terms related to Pinacidil

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.[1] It reduces blood pressure and peripheral resistance and produces fluid retention.[2]

References

  1. Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155.
  2. Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia, 31st, London: Royal Pharmaceutical Society, 2739 pages. ISBN 0-85369-342-0. 

External links


Linked-in.jpg