Pinacidil

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Pinacidil
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IUPAC name 3-cyano-1-(4-pyridyl)-2-(1,2,2-trimethylpropyl)guanidine
Identifiers
CAS number 85371-64-8
PubChem 4826
SMILES CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
Properties
Molecular formula C13H19N5
Molar mass 245.32346
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.[1] It reduces blood pressure and peripheral resistance and produces fluid retention.[2]

References

  1. Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155.
  2. Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia, 31st edition, London: Royal Pharmaceutical Society, 2739 pages. ISBN 0-85369-342-0. 

External links


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