Physiological agonism and antagonism
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Physiological agonism and antagonism is the mechanism of substances to induce the same ultimate effects in the body as other substances, as if they were receptor agonists or antagonists, but without binding to the same receptor.
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Examples
Physiological agonists
- Adrenaline induces platelet aggregation and so does hepatocyte growth factor (HGF)[1]. Thus, they are physiological agonists to each other.
Physiological antagonists
- There are several physiological antagonists that have antihistaminergic action. For instance, adrenaline raises arterial pressure through vasoconstriction mediated by β-adrenergic receptor activation, in contrast to the histamine effect of lowering arterial pressure. However, only such substances that bind and block the histamine receptor are true antihistamines.
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
