P2RY5

Purinergic receptor P2Y, G-protein coupled, 5
Identifiers
Symbol(s)	P2RY5; MGC120358; P2Y5
External IDs	OMIM: 609239 MGI: 1914418 Homologene: 55925
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	10161	67168
Ensembl	ENSG00000139679	ENSMUSG00000033446
Uniprot	P43657	Q8BMC0
Refseq	NM_005767 (mRNA) NP_005758 (protein)	NM_175116 (mRNA) NP_780325 (protein)
Location	Chr 13: 47.88 - 47.89 Mb	Chr 14: 71.97 - 71.97 Mb
Pubmed search	[1]	[2]

Purinergic receptor P2Y, G-protein coupled, 5, also known as P2RY5, is a human gene.

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.

See also

• P2Y receptor

Further reading

• Ralevic V, Burnstock G (1998). "Receptors for purines and pyrimidines.". Pharmacol. Rev. 50 (3): 413-92. PMID 9755289.
• Toguchida J, McGee TL, Paterson JC, et al. (1993). "Complete genomic sequence of the human retinoblastoma susceptibility gene.". Genomics 17 (3): 535-43. doi:10.1006/geno.1993.1368. PMID 7902321.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
• Herzog H, Darby K, Hort YJ, Shine J (1997). "Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene.". Genome Res. 6 (9): 858-61. PMID 8889552.
• Li Q, Schachter JB, Harden TK, Nicholas RA (1997). "The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.". Biochem. Biophys. Res. Commun. 236 (2): 455-60. doi:10.1006/bbrc.1997.6984. PMID 9240460.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
• Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.". Biochim. Biophys. Acta 1492 (1): 127-38. PMID 11004484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Ihara H, Hirukawa K, Goto S, Togari A (2005). "ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts.". Biochem. Biophys. Res. Commun. 326 (2): 329-34. doi:10.1016/j.bbrc.2004.11.037. PMID 15582581.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.