P-type ATPase
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| Calcium ATPase, E2-Pi state | ||
| Identifiers | ||
| Symbol | E1-E2_ATPase | |
| Pfam | PF00122 | |
| InterPro | IPR008250 | |
| PROSITE | PDOC00139 | |
| SCOP | 1eul | |
| OPM family | 22 | |
| OPM protein | 1wpg | |
| Available PDB structures:
2b8eC:407-414 1vfpA:93-341 1wpgC:93-341 1t5sA:93-341 1iwoB:93-341 1t5tA:93-341 1xp5A:93-341 1su4A:93-341 1kjuA:93-341 1wpeA:93-341 2agvA:93-341 1fquA:93-341 1u5nA:99-348 1mhsB:146-368 | ||
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P-type (or E1-E2-type) ATPases constitute a superfamily of cation transport enzymes, present both in prokaryota and eukaryota, whose members mediate membrane flux of all common biologically relevant cations[1]. The ATPases, that form an aspartyl phosphate intermediate in the course of ATP hydrolysis, can be divided into 4 major groups[2]:
- (1) Ca2+-transporting ATPases;
- (2) Na+/K+- and gastric H+/K+-transporting ATPases;
- (3) Plasma membrane H+-transporting ATPases (proton pumps) of plants, fungi and lower eukaryotes; and
- (4) all bacterial P-type ATPases, except the Mg2+-ATPase of Salmonella typhimurium, which is more similar to the eukaryotic sequences.
Human proteins containing this domain
- Na+/K+ transporting: ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP1B4
- Ca++ transporting: ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, ATP2C1
- Cu++ transporting: ATP7A, ATP7B
- Class I, type 8: ATP8A1, ATP8B1, ATP8B2, ATP8B3, ATP8B4
- Class II, type 9: ATP9A, ATP9B
- Class V, type 10: ATP10A, ATP10B, ATP10D
- Class VI, type 11: ATP11A, ATP11B, ATP11C
- H+/K+ transporting, nongastric: ATP12A
- type 13: ATP13A1, ATP13A2, ATP13A3, ATP13A4, ATP13A5
- ATP2C2;
- ATP4A;
- KIAA0195
See also
References
- ↑ Maguire ME, Smith DL, Tao T (1993). "Membrane topology of a P-type ATPase. The MgtB magnesium transport protein of Salmonella typhimurium". J. Biol. Chem. 268 (30): 22469-22479. PMID 8226755.
- ↑ Fagan MJ, Saier Jr MH (1994). "P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees". J. Mol. Evol. 38 (1): 57-99. PMID 8151716.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
