Oncocytoma
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| Oncocytoma Classification and external resources | |
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| Oncocytoma of the salivary gland. The photo shows the characteristic dark color of an oncocytoma, a rare type of benign neoplasm, at the left side of the image (the normal lobulated salivary gland tissue is to the right). Courtesy of Ed Uthman, MD]] | |
| ICD-O: | 8290/0 |
| DiseasesDB | 31956 |
| eMedicine | med/1045 |
| MeSH | D018249 |
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Overview
An oncocytoma is a tumor made up of oncocytes, which are a special kind of cells.
Pathophysiology and Etiology
This is an epithelial tumor composed of large, eosinophilic cells having small, round, benign-appearing nuclei that have large nucleoli. It is thought to arise from the intercalated cells of collecting ducts. It is not an uncommon tumor, accounting for approximately 5% to 15% of surgically resected renal neoplasms. Ultrastructurally, the eosinophilic cells have numerous mitochondria. In gross appearance, the tumors are tan or mahogany brown, relatively homogeneous, and usually well encapsulated. However, they may achieve a large size (up to 12 cm in diameter). Although anecdotal cases with metastases have been reported, the tumor is considered benign. There are some familial cases in which these tumors are multicentric rather than solitary. [1]
Symptoms
Most cases are symptomatic. Symptoms when present include hematuria or blood in urine, flank pain, abdominal mass. The majority of the time an oncocytoma is detected incidentally while investigating another condition.
See also
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
