OR4F4

Olfactory receptor, family 4, subfamily F, member 4
Identifiers
Symbol(s)	OR4F4; OLA-7501; OR4F18; OR4F11P; OR4F19
External IDs	Homologene: 88410
Gene ontology Molecular Function: • receptor activity • olfactory receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus
Orthologs
	Human	Mouse
Entrez	26682	623583
Ensembl	ENSG00000186092	na
Uniprot	Q96R69	na
Refseq	NM_001004195 (mRNA) NP_001004195 (protein)	XM_888068 (mRNA) XP_893161 (protein)
Location	Chr 15: 100.28 - 100.28 Mb	na
Pubmed search	[1]	[2]

Olfactory receptor, family 4, subfamily F, member 4, also known as OR4F4, is a human gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.". Hum. Mol. Genet. 7 (1): 13-26. PMID 9384599.
• Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.". Hum. Mol. Genet. 10 (21): 2363-72. PMID 11689483.
• Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.". Hum. Mol. Genet. 10 (21): 2373-83. PMID 11689484.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295-302. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9. PMID 14983052.

External links

• MeSH OR4F4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub