OR3A4

Olfactory receptor, family 3, subfamily A, member 4
Identifiers
Symbol(s)	OR3A4; OR17-16; OR17-24; OLFRA05; OLFRA06; OR17-13; OR17-25; OR24; OR25; OR3A4P; OR3A5P
External IDs	MGI: 3030233 Homologene: 27325
Gene ontology Molecular Function: • receptor activity • olfactory receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus
Orthologs
	Human	Mouse
Entrez	390756	259006
Ensembl	ENSG00000180068	ENSMUSG00000043692
Uniprot	P47883	na
Refseq	NM_001005334 (mRNA) NP_001005334 (protein)	NM_147004 (mRNA) NP_667215 (protein)
Location	Chr 17: 3.16 - 3.16 Mb	Chr 11: 73.87 - 73.87 Mb
Pubmed search	[1]	[2]

Olfactory receptor, family 3, subfamily A, member 4, also known as OR3A4, is a human gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.". Hum. Mol. Genet. 3 (2): 229-35. PMID 8004088.
• Glusman G, Clifton S, Roe B, Lancet D (1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity.". Genomics 37 (2): 147-60. doi:10.1006/geno.1996.0536. PMID 8921386.
• Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.". Genomics 63 (2): 227-45. doi:10.1006/geno.1999.6030. PMID 10673334.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295-302. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9. PMID 14983052.

External links

• MeSH OR3A4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub