OR1J2

Olfactory receptor, family 1, subfamily J, member 2
Identifiers
Symbol(s)	OR1J2; FLJ16828; HG152; HSA5; OR1J3; OR1J5; OR9-19; OST044
External IDs	MGI: 3030186 Homologene: 73996
Gene ontology Molecular Function: • receptor activity • olfactory receptor activity Cellular Component: • integral to membrane Biological Process: • G-protein coupled receptor protein signaling pathway • sensory perception of smell
Orthologs
	Human	Mouse
Entrez	26740	258942
Ensembl	na	ENSMUSG00000053146
Refseq	NM_054107 (mRNA) NP_473448 (protein)	NM_146940 (mRNA) NP_667151 (protein)
Location	na	Chr 2: 36.69 - 36.69 Mb
Pubmed search	[1]	[2]

Olfactory receptor, family 1, subfamily J, member 2, also known as OR1J2, is a human gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Parmentier M, Libert F, Schurmans S, et al. (1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells.". Nature 355 (6359): 453-5. doi:10.1038/355453a0. PMID 1370859.
• Rouquier S, Blancher A, Giorgi D (2000). "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2870-4. doi:10.1073/pnas.040580197. PMID 10706615.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295-302. PMID 12213199.
• Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural selection on the olfactory receptor gene family in humans and chimpanzees.". Am. J. Hum. Genet. 73 (3): 489-501. doi:10.1086/378132. PMID 12908129.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9. PMID 14983052.

External links

• MeSH OR1J2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub