OR1A1
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| Olfactory receptor, family 1, subfamily A, member 1
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| Identifiers | ||||||||||||||
| Symbol(s) | OR1A1; OR17-7 | |||||||||||||
| External IDs | MGI: 1333770 Homologene: 8219 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8383 | 258706 | ||||||||||||
| Ensembl | ENSG00000172146 | ENSMUSG00000070377 | ||||||||||||
| Uniprot | Q9P1Q5 | na | ||||||||||||
| Refseq | NM_014565 (mRNA) NP_055380 (protein) | NM_146711 (mRNA) NP_666922 (protein) | ||||||||||||
| Location | Chr 17: 3.07 - 3.07 Mb | Chr 11: 74.02 - 74.02 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Olfactory receptor, family 1, subfamily A, member 1, also known as OR1A1, is a human gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
See also
References
Further reading
- Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.". Genomics 63 (2): 227-45. doi:10.1006/geno.1999.6030. PMID 10673334.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295-302. PMID 12213199.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub
G protein-coupled receptors: olfactory receptors | |
|---|---|
| Family 1 | A1 - A2 - B1 - C1 - D2 - D4 - D5 - E1 - E2 - F1 - F2 - G1 - I1 - J1 - J2 - J4 - K1 - L1 - L3 - L4 - L6 - L8 - M1 - N1 - N2 - Q1 - S1 - S2 |
| Family 2 | A2 - A4 - A5 - A7 - A12 - A14 - A25 - A42 - AE1 - AG1 - AG2 - AJ1 - AK2 - AP1 - AT4 - B2 - B3 - B6 - B8 - B11 - C1 - C3 - D2 - D3 - F1 - F2 - G2 - G3 - G6 - H1 - H2 - J1 - J2 - J3 - K2 - L2 - L3 - L5 - L8 - L13 - M2 - M3 - M4 - M5 - M7 - S2 - T1 - T2 - T3 - T4 - T5 - T6 - T8 - T10 - T11 - T12 - T27 - T29 - T33 - T34 - T35 - V1 - V2 - W1 - W3 - W5 - Y1 - Z1 |
| Family 3 | A1 - A2 - A3 - A4 |
| Family 4 | A5 - A15 - A16 - A47 - B1 - C3 - C5 - C6 - C11 - C12 - C13 - C15 - C16 - C45 - C46 - D1 - D2 - D5 - D6 - D9 - D10 - D11 - E2 - F4 - F5 - F6 - F15 - F17 - F21 - F29 - K1 - K2 - K3 - K5 - K13 - K14 - K15 - K17 - L1 - M1 - M2 - N2 - N4 - N5 - P4 - Q3 - S1 - S2 - X1 - X2 |
| Family 5 | A1 - A2 - AC2 - AK2 - AK3 - AN1 - AP2 - AR1 - AS1 - AT1 - AU1 - AY1 - B2 - B3 - B12 - B17 - B21 - BF1 - BU1 - C1 - D13 - D14 - D16 - D18 - F1 - H1 - H2 - H6 - H14 - H15 - I1 - J2 - K1 - K2 - K3 - K4 - L1 - L2 - M1 - M3 - M8 - M9 - M10 - M11 - P2 - P3 - R1 - T1 - T2 - T3 - U1 - V1 - W2 |
| Family 6 | A2 - B1 - B2 - B3 - C1 - C2 - C3 - C4 - C6 - C65 - C68 - C70 - C74 - C75 - C76 - F1 - J1 - K2 - K3 - K6 - M1 - N1 - N2 - P1 - Q1 - S1 - T1 - V1 - X1 - Y1 |
| Family 7 | A2 - A5 - A10 - A17 - C1 - C2 - D2 - D4 - E24 - G1 - G2 - G3 |
| Family 8 | A1 - B2 - B3 - B4 - B8 - B12 - D1 - D2 - D4 - G1 - G2 - G5 - H1 - H2 - H3 - I2 - J1 - J3 - K1 - K3 - K5 - S1 - U1 |
| Family 9 | A2 - A4 - G1 - G4 - I1 - K2 - Q1 - Q2 |
| Family 10 | A2 - A3 - A4 - A5 - A6 - A7 - AD1 - C1 - D4 - G2 - G3 - G4 - G6 - G7 - G8 - G9 - H1 - H2 - H3 - H4 - H5 - J1 - J3 - J5 - J6 - K1 - K2 - P1 - Q1 - R2 - S1 - T2 - V1 - W1 - X1 - Z1 |
| Family 11 | A1 - G2 - H1 - H4 - H6 - L1 |
| Family 12 | D2 - D3 |
| Family 13 | A1 - C2 - C3 - C4 - C5 - C8 - C9 - D1 - F1 - G1 - H1 - J1 |
| Family 17 | -1 |
| Family 51 | A2 - A4 - A7 - B2 - B4 - B5 - B6 - D1 - E1 - E2 - F1 - F2 - G1 - G2 - H1 - I1 - I2 - L1 - M1 - Q1 - S1 - T1 - V1 |
| Family 52 | A1 - A4 - A5 - B2 - B4 - B6 - D1 - E1 - E2 - E4 - E5 - E6 - E8 - H1 - I1 - I2 - J3 - K1 - K2 - L1 - L2 - M1 - N1 - N2 - N4 - N5 - P1 - R1 - W1 |
| Family 56 | A1 - A3 - A4 - B1 - B4 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
