OR10A5

Olfactory receptor, family 10, subfamily A, member 5
Identifiers
Symbol(s)	OR10A5; JCG6; OR10A1; OR11-403
External IDs	OMIM: 608493 MGI: 3030547 Homologene: 17470
Gene ontology Molecular Function: • receptor activity • olfactory receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • sensory perception of smell • response to stimulus
Orthologs
	Human	Mouse
Entrez	144124	259036
Ensembl	ENSG00000166363	ENSMUSG00000073898
Uniprot	Q9H207	na
Refseq	NM_178168 (mRNA) NP_835462 (protein)	NM_147034 (mRNA) NP_667245 (protein)
Location	Chr 11: 6.82 - 6.82 Mb	Chr 7: 106.83 - 106.83 Mb
Pubmed search	[1]	[2]

Olfactory receptor, family 10, subfamily A, member 5, also known as OR10A5, is a human gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Buettner JA, Glusman G, Ben-Arie N, et al. (1998). "Organization and evolution of olfactory receptor genes on human chromosome 11.". Genomics 53 (1): 56-68. doi:10.1006/geno.1998.5422. PMID 9787077.
• Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390-5. doi:10.1073/pnas.131215398. PMID 11416212.
• Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library.". Chem. Senses 26 (9): 1157-66. PMID 11705801.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295-302. PMID 12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.

External links

• MeSH OR10A5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub