Non small cell lung cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Non-small cell lung cancer may be classified according to the WHO histological classification system into 3 main types; Squamous cell carcinoma, lung adenocarcinoma, and large cell carcinoma. Other less common subtypes include adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumor of the lung, and carcinomas of the lung of salivary gland type.

Classification

WHO histological classification system
Adapted from WHO/IARC (2006)
Main types Subtypes Prevalence
Adenocarcinoma
  • Adenocarcinoma, mixed
  • Acinar adenocarcinoma
  • Papillary adenocarcinoma
  • Bronchioloalveolar carcinoma
  • Nonmucinous
  • Mucinous
  • Mixed nonmucinous and mucinous or indeterminate
  • Solid adenocarcinoma with mucin production
  • Fetal adenocarcinoma
  • Mucinous (“colloid”) carcinoma
  • Mucinous cystadenocarcinoma
  • Signet ring adenocarcinoma
  • Clear cell adenocarcinoma
  • 40% of lung cancers
Squamous cell carcinoma
  • Papillary
  • Clear cell
  • Small cell
  • Basaloid
  • 25% of lung cancers
Large cell carcinoma
  • Large cell neuroendocrine carcinoma
  • Basaloid carcinoma
  • Lymphoepithelioma-like carcinoma
  • Clear cell carcinoma
  • Large cell carcinoma with rhabdoid phenotype
  • 10% of lung cancer
Less common types
Adenosquamous carcinoma
  • No subtypes
  • Less than 5%
Sarcomatoid carcinoma
  • Pleomorphic carcinoma
  • Spindle cell carcinoma
  • Giant cell carcinoma
  • Carcinosarcoma
  • Pulmonary blastoma
  • Less than 5%
Carcinoid tumor
  • Typical carcinoid
  • Atypical carcinoid
  • Less than 5%
Salivary gland tumor
  • Mucoepidermoid carcinoma
  • Adenoid cystic carcinoma
  • Epithelial-myoepithelial carcinoma
  • Less than 5%

References

  1. Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.
  2. Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
  3. Raz DJ, He B, Rosell R, Jablons DM (2006). "Bronchioloalveolar carcinoma: a review". Clin Lung Cancer. 7 (5): 313–22. doi:10.3816/CLC.2006.n.012. PMID 16640802.
  4. Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016