Neuronal calcium sensor
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Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.[1]
Members of NCS family
- NCS1 (Frequenin)
- visinin
- VILIP-1 (Visinin-like-protein-1)
- hippocalcin
- recoverin
- GCAP
- neurocalcin
- visinin
- Potassium Channel interacting proteins (KChIPs 1-4), including:
- Calsenilin or DREAM/KChIP-3 (downstream regulatory element antagonist modulator/potassium channel interacting protein) - Calsenilin like protein (KChIP-4)
References
- ↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203-9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
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Cell signaling: calcium signaling | |
|---|---|
| Second messengers | IP3 - NAADP - cADPR |
| Intracellular calcium store gates | IP3 receptor - Ryanodine receptor - putative NAADP receptor |
| Calcium pumps and exchangers | SERCA - Na/Ca antiport - Ca/H antiport |
| calcium binding protein domains | EF hand domain - C2 domain |
| Calcium based molecular switches, and kinases | Troponin C - CaM - CaM kinases - PKC - NCS |
| Intracellular calcium chelators (calcium buffers) and calcium sensors | Calbindin - S100 - pervalbumin - Calretinin - Calsequestrin - Sarcalumenin - Phospholamban - Synaptotagmins |
| Calcium dependent proteases | Calpain |
| Calcium dependent cytoskeleton remodeling proteins | Gelsolin |
| Cell membrane calcium channels | VDCC - TRP - NMDA receptor - AMPA receptor - 5-HT3 receptor - P2X Receptor |
| Calcium regulated chaperones | calreticulin - calnexin |
| Calcium based adhesion molecules | Cadherin |
| Calcium homeostasis | Parathyroid hormone - Calcitonin - calcium receptor - vitamin D |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
