Nephrotoxicity

Jump to navigation Jump to search

WikiDoc Resources for Nephrotoxicity

Articles

Most recent articles on Nephrotoxicity

Most cited articles on Nephrotoxicity

Review articles on Nephrotoxicity

Articles on Nephrotoxicity in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Nephrotoxicity

Images of Nephrotoxicity

Photos of Nephrotoxicity

Podcasts & MP3s on Nephrotoxicity

Videos on Nephrotoxicity

Evidence Based Medicine

Cochrane Collaboration on Nephrotoxicity

Bandolier on Nephrotoxicity

TRIP on Nephrotoxicity

Clinical Trials

Ongoing Trials on Nephrotoxicity at Clinical Trials.gov

Trial results on Nephrotoxicity

Clinical Trials on Nephrotoxicity at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Nephrotoxicity

NICE Guidance on Nephrotoxicity

NHS PRODIGY Guidance

FDA on Nephrotoxicity

CDC on Nephrotoxicity

Books

Books on Nephrotoxicity

News

Nephrotoxicity in the news

Be alerted to news on Nephrotoxicity

News trends on Nephrotoxicity

Commentary

Blogs on Nephrotoxicity

Definitions

Definitions of Nephrotoxicity

Patient Resources / Community

Patient resources on Nephrotoxicity

Discussion groups on Nephrotoxicity

Patient Handouts on Nephrotoxicity

Directions to Hospitals Treating Nephrotoxicity

Risk calculators and risk factors for Nephrotoxicity

Healthcare Provider Resources

Symptoms of Nephrotoxicity

Causes & Risk Factors for Nephrotoxicity

Diagnostic studies for Nephrotoxicity

Treatment of Nephrotoxicity

Continuing Medical Education (CME)

CME Programs on Nephrotoxicity

International

Nephrotoxicity en Espanol

Nephrotoxicity en Francais

Business

Nephrotoxicity in the Marketplace

Patents on Nephrotoxicity

Experimental / Informatics

List of terms related to Nephrotoxicity

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Nephrotoxicity is a poisonous effect of some substances, both toxic chemicals and medication, on the kidney. There are various forms of toxicity. [2] Nephrotoxicity should not be confused with the fact that some medications have a predominantly renal excretion and need their dose adjusted for the decreased renal function (e.g. heparin).

Nephrotoxins are chemicals displaying nephrotoxicity.

The nephrotoxic effect of most drugs is more profound in patients who already suffer from renal impairment. Some drugs may affect renal function in more than one way.

Types of toxicity

Cardiovascular

Direct tubular effect

Acute interstitial nephritis

Acute glomerulonephritis

Causes of diabetes insipidus

Other nephrotoxins

  • Heavy metals interfere with enzymes of energy metabolism.
  • Aristolochic acid, found in some plants and, more dangerously, in some herbal supplements derived from those plants, has been shown to have nephrotoxic effects on humans.

Medications Causing Nephrotoxicity

Surveillance

Nephrotoxicity is usually monitored through a simple blood test. An elevated level of creatinine indicates poor renal function. Normal creatinine levels are between 80 - 120 mm/l. In interventional radiology, a patients' creatinine levels are all checked prior to a procedure. Should an elevated creatinine level be found, a special contrast medium or radiocontrast is used which is less harmful for the patient.

Creatinine clearance is another measure of renal function, which may be more useful clinically when dealing with patients with early kidney disease.

References

  1. ^ Galley HF. Can acute renal failure be prevented? J R Coll Surg Edinb 2000;45(1):44-50. Fulltext. PMID 10815380.

See also



de:Nephrotoxin nl:Nefrotoxiciteit

Template:WH Template:WikiDoc Sources