Neosalvarsan

Jump to navigation Jump to search

Template:Chembox new

WikiDoc Resources for Neosalvarsan

Articles

Most recent articles on Neosalvarsan

Most cited articles on Neosalvarsan

Review articles on Neosalvarsan

Articles on Neosalvarsan in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Neosalvarsan

Images of Neosalvarsan

Photos of Neosalvarsan

Podcasts & MP3s on Neosalvarsan

Videos on Neosalvarsan

Evidence Based Medicine

Cochrane Collaboration on Neosalvarsan

Bandolier on Neosalvarsan

TRIP on Neosalvarsan

Clinical Trials

Ongoing Trials on Neosalvarsan at Clinical Trials.gov

Trial results on Neosalvarsan

Clinical Trials on Neosalvarsan at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Neosalvarsan

NICE Guidance on Neosalvarsan

NHS PRODIGY Guidance

FDA on Neosalvarsan

CDC on Neosalvarsan

Books

Books on Neosalvarsan

News

Neosalvarsan in the news

Be alerted to news on Neosalvarsan

News trends on Neosalvarsan

Commentary

Blogs on Neosalvarsan

Definitions

Definitions of Neosalvarsan

Patient Resources / Community

Patient resources on Neosalvarsan

Discussion groups on Neosalvarsan

Patient Handouts on Neosalvarsan

Directions to Hospitals Treating Neosalvarsan

Risk calculators and risk factors for Neosalvarsan

Healthcare Provider Resources

Symptoms of Neosalvarsan

Causes & Risk Factors for Neosalvarsan

Diagnostic studies for Neosalvarsan

Treatment of Neosalvarsan

Continuing Medical Education (CME)

CME Programs on Neosalvarsan

International

Neosalvarsan en Espanol

Neosalvarsan en Francais

Business

Neosalvarsan in the Marketplace

Patents on Neosalvarsan

Experimental / Informatics

List of terms related to Neosalvarsan


Neosalvarsan is a synthetic antibiotic that is an organoarsenic compound. It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis. Because both of these arsenicals carried considerable risk of side-effects, they were replaced for this indication by penicillin in the 1940s.

Both salvarsan and neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications. This scheme is the basis for most modern pharmaceutical research. Both salvarsan and neosalvarsan are prodrugs, that is to say that they are metabolised to the active drug in the body.

Structure

The structure of Salvarsan and, presumably this derivative, was once believed to feature an As=As bond as shown in the figure.. In 2005, Salvarsan was shown to be a mixture of the cyclic trimer and a pentamer.[1][2] The revised structure features As-As single bonds, not double bonds.

References

  1. "accsnet.ne.jp". Retrieved 2007-08-25.
  2. Lloyd NC, Morgan HW, Nicholson BK, Ronimus RS (2005). "The composition of Ehrlich's salvarsan: resolution of a century-old debate". Angewandte Chemie International Edition in English. 44 (6): 941–4. doi:10.1002/anie.200461471. PMID 15624113.


Template:WH Template:WikiDoc Sources