Müllerian duct

Müllerian duct
Urogenital sinus of female human embryo of eight and a half to nine weeks old.
Tail end of human embryo, from eight and a half to nine weeks old.
Latin	d. paramesonephricus
Gray's	subject #252 1206
Carnegie stage	17
Precursor	Intermediate mesoderm
MeSH	Mullerian+Ducts
Dorlands/Elsevier	d_29/12315002

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The Müllerian ducts (or paramesonephric ducts) are paired ducts of the embryo which run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, it will develop to form the fallopian tubes, uterus, and the upper portion of the vagina. It is tissue of mesodermal origin.

Development

Müllerian duct develops in females and degenerates in males.

Regulation of development

The development of the Müllerian ducts is controlled by the presence or absence of "AMH", or Anti-müllerian hormone (also known as "MIF" for "Müllerian inhibiting factor", or "MIH" for "Müllerian inhibiting hormone").

male embryogenesis	The testes produce AMH and as a result the development of the Müllerian ducts is inhibited.	Disturbances can lead to persistent müllerian duct syndrome.	The ducts disappear except for the vestigial vagina masculina and the appendix testis.
female embryogenesis	The absence of AMH results in the development of female reproductive organs, as noted above.	Disturbance in the development may result in uterine absence (Mullerian agenesis) or uterine malformations.	The ducts develop into the upper vagina, cervix, uterus and oviducts.

Eponym

They are named after Johannes Peter Müller, a physiologist who described these ducts in his text "Bildungsgeschichte der Genitalien" in 1830.

Additional images

• 

  Enlarged view from the front of the left Wolffian body before the establishment of the distinction of sex.

• 

  Transverse section of human embryo eight and a half to nine weeks old.

• 

  Müllerian duct (blue) develops in females (middle image) and degenerates in males (bottom).

See also

• Defeminization
• prostatic utricle
• List of homologues of the human reproductive system
• Sexual differentiation
• Wolffian duct

External links

• Embryology at UNC genital-010

Cost Effectiveness of Müllerian duct

| group5 = Clinical Trials Involving Müllerian duct | list5 = Ongoing Trials on Müllerian duct at Clinical Trials.gov • Trial results on Müllerian duct • Clinical Trials on Müllerian duct at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Müllerian duct | list6 = US National Guidelines Clearinghouse on Müllerian duct • NICE Guidance on Müllerian duct • NHS PRODIGY Guidance • FDA on Müllerian duct • CDC on Müllerian duct

| group7 = Textbook Information on Müllerian duct | list7 = Books and Textbook Information on Müllerian duct

| group8 = Pharmacology Resources on Müllerian duct | list8 = AND (Dose)}} Dosing of Müllerian duct • AND (drug interactions)}} Drug interactions with Müllerian duct • AND (side effects)}} Side effects of Müllerian duct • AND (Allergy)}} Allergic reactions to Müllerian duct • AND (overdose)}} Overdose information on Müllerian duct • AND (carcinogenicity)}} Carcinogenicity information on Müllerian duct • AND (pregnancy)}} Müllerian duct in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Müllerian duct •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Müllerian duct | list9 = AND (pharmacogenomics)}} Genetics of Müllerian duct • AND (pharmacogenomics)}} Pharmacogenomics of Müllerian duct • AND (proteomics)}} Proteomics of Müllerian duct

| group10 = Newstories on Müllerian duct | list10 = Müllerian duct in the news • Be alerted to news on Müllerian duct • News trends on Müllerian duct</small>

| group11 = Commentary on Müllerian duct | list11 = Blogs on Müllerian duct

| group12 = Patient Resources on Müllerian duct | list12 = Patient resources on Müllerian duct • Discussion groups on Müllerian duct • Patient Handouts on Müllerian duct • Directions to Hospitals Treating Müllerian duct • Risk calculators and risk factors for Müllerian duct

| group13 = Healthcare Provider Resources on Müllerian duct | list13 = Symptoms of Müllerian duct • Causes & Risk Factors for Müllerian duct • Diagnostic studies for Müllerian duct • Treatment of Müllerian duct

| group14 = Continuing Medical Education (CME) Programs on Müllerian duct | list14 = CME Programs on Müllerian duct

| group15 = International Resources on Müllerian duct | list15 = Müllerian duct en Espanol • Müllerian duct en Francais

| group16 = Business Resources on Müllerian duct | list16 = Müllerian duct in the Marketplace • Patents on Müllerian duct

| group17 = Informatics Resources on Müllerian duct | list17 = List of terms related to Müllerian duct

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