Macrogol

Macrogol
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a603032
ATC code	A06AD15 (WHO) ;
Identifiers
	IUPAC name Not available;
CAS Number	25322-68-3 ;
ChemSpider	NA ;
UNII	3WJQ0SDW1A;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	H-(OCH2CH2)n-OH
Molar mass	Not available
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Macrogol is the International Nonproprietary Name (INN) for polyethylene glycol. Macrogols have been used as laxatives, i.e. to treat constipation.^[1]

They are also used as excipients in pharmaceutical products where lower molecular weight variants are used as solvents in oral liquids and soft capsules. Solid variants are used as ointment bases, tablet bindings, film coatings and lubricants.^[2]

Popular types include:

macrogol 3350^[3]
macrogol 4000^[4]
macrogol 6000^[5]

The number represents the average molecular weight of the polyethylene glycol. Combining different molecular weights provides some control over the consistency.^[2]

Polyethylene glycol

Available forms

Macrogol (polyethylene glycol) is sold as non-prescription preparation in powder form under trade names SoftLax, Purelax, Miralax, Glycoprep, Movicol, Macrogol (generic), Cololyt and Osmolax, among others. It is dissolved in a glass of water to create a clear, tasteless and odorless solution and is swallowed.

References

↑ Zangaglia R; Martignoni E; Glorioso M; et al. (2007). "Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo-controlled study". Mov. Disord. 22 (9): 1239–44. doi:10.1002/mds.21243. PMID 17566120. Unknown parameter |author-separator= ignored (help)
↑ ^2.0 ^2.1 Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 287. ISBN 9780849335853.
↑ Hardikar W, Cranswick N, Heine RG (2007). "Macrogol 3350 plus electrolytes for chronic constipation in children: a single-centre, open-label study". Journal of Paediatrics and Child Health. 43 (7–8): 527–31. doi:10.1111/j.1440-1754.2007.01116.x. PMID 17635680.
↑ "CID 27175 -- PubChem Compound Summary". Retrieved 2008-01-18.
↑ Hyry H, Vuorio A, Varjonen E, Skyttä J, Mäkinen-Kiljunen S (2006). "Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets". Allergy. 61 (8): 1021. doi:10.1111/j.1398-9995.2006.01083.x. PMID 16867059.

Template:Laxatives

Template:Gastrointestinal-drug-stub

[Zangaglia_2007-1] Zangaglia R; Martignoni E; Glorioso M; et al. (2007). "Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo-controlled study". Mov. Disord. 22 (9): 1239–44. doi:10.1002/mds.21243. PMID 17566120. Unknown parameter |author-separator= ignored (help)

[Smolinske-2] 2.0 ^2.1 Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 287. ISBN 9780849335853.

[Hardikar_et_al._2007-3] Hardikar W, Cranswick N, Heine RG (2007). "Macrogol 3350 plus electrolytes for chronic constipation in children: a single-centre, open-label study". Journal of Paediatrics and Child Health. 43 (7–8): 527–31. doi:10.1111/j.1440-1754.2007.01116.x. PMID 17635680.

[PubChem_Compound_Summary_2008-4] "CID 27175 -- PubChem Compound Summary". Retrieved 2008-01-18.

[Hyry_et_al._2006-5] Hyry H, Vuorio A, Varjonen E, Skyttä J, Mäkinen-Kiljunen S (2006). "Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets". Allergy. 61 (8): 1021. doi:10.1111/j.1398-9995.2006.01083.x. PMID 16867059.

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Macrogol

Available forms

References

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