Machine perfusion

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Machine perfusion

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Machine perfusion (MP) is a technique used in organ transplantation as a means of preserving the organs which are to be transplanted. So far it has mainly been used in kidney transplantation. It is an alternative to cold storage (CS). Its clinical and cost-effectiveness are still subject to research.[1]

Hypothermic perfusion has given the longest storage time for canine kidneys with the best result being 8 day storage.[1] This experimental model used a storage temperature of 8°C and a Plasma Protein Fraction (PPF) based perfusate.[1] The octanoic acid content of PPF was found to influence the results of preservation in five-day storage.[1] Both octanoic acid and oleic acid stimulated oxygen consumption to a similar degree during hypothermic perfusion[1] suggesting that the detrimental effect of Octanoic acid was due to direct metabolic stimulation rather than uncoupling of oxidatative phosphorylation.[1]

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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