Ménétrier's disease

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Ménétrier's disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Ménétrier's disease (also known as hyperplastic hypersecretory gastropathy, and named after a French physician Pierre Eugène Ménétrier, 1859-1935), is a disorder in which the gastric mucosal folds (rugae) are enlarged[1] (and the total weight of the stomach is increased), making the surface of the stomach look a bit like the brain gyri. The altered gastric mucosa secretes massive amounts of mucus, resulting in low plasma protein levels. The tissue may be inflamed and may contain ulcers. The disease also causes glands in the stomach to waste away and causes the body to lose fluid containing a protein called albumin.

There are two forms of the disease: a childhood form and an adult form. The childhood form has a better prognosis. It affects boys and girls equally, most often after they have a viral illness caused by cytomegalovirus (CMV) or a bacterial infection caused by Helicobacter pylori. Children are not born with this disease, and it is not passed from parents to their children.[2]. The adult form linked with overexpression of transforming growth factor alpha (TGF-α). The adult variety is four times more common in men, primarily affecting men between ages 30 and 60.

The presenting symptoms are

Ménétrier's disease increases a person's risk of stomach cancer.[3]

Microscopically, the disease is characterized by hyperplasia of the crypts, which are elongated and may appear cystic or corkscrew-like. Since it predisposes to stomach cancer, periodic endoscopic surveillance is mandated. CMV-related Ménétrier is often self-limited.

The disease must be diagnosed by x-ray (rare) or endoscopy and biopsy of the stomach. In adults, treatment may include medications to relieve ulcer symptoms and treat inflammation, and a high-protein diet. Part or all of the stomach may need to be removed if the disease is severe. Pediatric cases are normally treated for symptoms with the disease clearing up in weeks to months.

Other forms of hyperplastic gastropathy include Zollinger-Ellison syndrome.

References

  1. http://www.gpnotebook.co.uk/cache/-2026569705.htm
  2. http://www.madisonsfoundation.org/content/3/1/display.asp?did=413
  3. http://www.mamashealth.com/stomach/menetrier.asp

Additional Resources

  • Rubin's Pathology, Clinicopathological Foundations of Medicine, 4th edition, Rubin, Gorstein, Rubin, Schwarting, Strayer. Lippincott Williams & Wilkins. ISBN 0-7817-4733-3
Cost Effectiveness of Ménétrier's disease

| group5 = Clinical Trials Involving Ménétrier's disease | list5 = Ongoing Trials on Ménétrier's disease at Clinical Trials.govTrial results on Ménétrier's diseaseClinical Trials on Ménétrier's disease at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Ménétrier's disease | list6 = US National Guidelines Clearinghouse on Ménétrier's diseaseNICE Guidance on Ménétrier's diseaseNHS PRODIGY GuidanceFDA on Ménétrier's diseaseCDC on Ménétrier's disease


| group7 = Textbook Information on Ménétrier's disease | list7 = Books and Textbook Information on Ménétrier's disease


| group8 = Pharmacology Resources on Ménétrier's disease | list8 = AND (Dose)}} Dosing of Ménétrier's diseaseAND (drug interactions)}} Drug interactions with Ménétrier's diseaseAND (side effects)}} Side effects of Ménétrier's diseaseAND (Allergy)}} Allergic reactions to Ménétrier's diseaseAND (overdose)}} Overdose information on Ménétrier's diseaseAND (carcinogenicity)}} Carcinogenicity information on Ménétrier's diseaseAND (pregnancy)}} Ménétrier's disease in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Ménétrier's disease


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Ménétrier's disease | list9 = AND (pharmacogenomics)}} Genetics of Ménétrier's diseaseAND (pharmacogenomics)}} Pharmacogenomics of Ménétrier's diseaseAND (proteomics)}} Proteomics of Ménétrier's disease


| group10 = Newstories on Ménétrier's disease | list10 = Ménétrier's disease in the newsBe alerted to news on Ménétrier's diseaseNews trends on Ménétrier's disease</small>


| group11 = Commentary on Ménétrier's disease | list11 = Blogs on Ménétrier's disease

| group12 = Patient Resources on Ménétrier's disease | list12 = Patient resources on Ménétrier's diseaseDiscussion groups on Ménétrier's diseasePatient Handouts on Ménétrier's diseaseDirections to Hospitals Treating Ménétrier's diseaseRisk calculators and risk factors for Ménétrier's disease


| group13 = Healthcare Provider Resources on Ménétrier's disease | list13 = Symptoms of Ménétrier's diseaseCauses & Risk Factors for Ménétrier's diseaseDiagnostic studies for Ménétrier's diseaseTreatment of Ménétrier's disease

| group14 = Continuing Medical Education (CME) Programs on Ménétrier's disease | list14 = CME Programs on Ménétrier's disease

| group15 = International Resources on Ménétrier's disease | list15 = Ménétrier's disease en EspanolMénétrier's disease en Francais

| group16 = Business Resources on Ménétrier's disease | list16 = Ménétrier's disease in the MarketplacePatents on Ménétrier's disease

| group17 = Informatics Resources on Ménétrier's disease | list17 = List of terms related to Ménétrier's disease


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