Lymphangiosarcoma
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| Lymphangiosarcoma Classification and external resources | |
| ICD-O: | 9170/3 |
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| DiseasesDB | 29095 |
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Most recent articles on Lymphangiosarcoma Most cited articles on Lymphangiosarcoma | |
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Cochrane Collaboration on Lymphangiosarcoma | |
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Ongoing Trials on Lymphangiosarcoma at Clinical Trials.gov Trial results on Lymphangiosarcoma Clinical Trials on Lymphangiosarcoma at Google
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US National Guidelines Clearinghouse on Lymphangiosarcoma NICE Guidance on Lymphangiosarcoma
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Patient resources on Lymphangiosarcoma Discussion groups on Lymphangiosarcoma Patient Handouts on Lymphangiosarcoma Directions to Hospitals Treating Lymphangiosarcoma Risk calculators and risk factors for Lymphangiosarcoma
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Causes & Risk Factors for Lymphangiosarcoma | |
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Lymphangiosarcoma is a rare malignant tumor which occurs in long-standing cases of Primary or Secondary Lymphedema. It involves either the upper or lower lymphedemateous extremities but is most common in upper extremities.
Presentation
The sarcoma first appears as a bruise mark, a purplish discolorization or a tender skin nodule in the extremity, typically on the anterior surface. It progresses to an ulcer with crusting, and finally to an extensive necrosis involving the skin and subcutaneous tissue. It metastasizes quickly.
Causes
It was previously a relatively common complication of the massive lymphedema of the arm which followed removal of axillary (arm pit) lymph nodes and lymphatic channels as part of the classical Halstedian radical mastectomy, as a treatment for breast cancer. The classical radical mastectomy was abandoned in most areas of the world in the late 1960's to early 1970's, being replaced by the much more conservative modified radical mastectomy and, more recently, by segmental breast tissue excision and radiation therapy. Because of this change in clinical practice lymphedema is now a rarity following breast cancer treatment - and post-mastectomy lymphangiosarcoma is now vanishingly rare. When it occurs following mastectomy it is known as Stewart-Treves Syndrome.
References
Cancer: Principles & Practice of Oncology, 6th Edition, DeVita, Hellman and Rosenberg, p. 1853
See also
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
