KLK2
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| Kallikrein-related peptidase 2
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| Identifiers | |||||||||||
| Symbol(s) | KLK2; KLK2A2; MGC12201; hK2 | ||||||||||
| External IDs | OMIM: 147960 MGI: 892019 Homologene: 68141 | ||||||||||
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| RNA expression pattern | |||||||||||
| Image:PBB GE KLK2 209854 s at tn.png Image:PBB GE KLK2 209855 s at tn.png | |||||||||||
| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 3817 | 16623 | |||||||||
| Ensembl | ENSG00000167751 | ENSMUSG00000063133 | |||||||||
| Uniprot | P20151 | Q8C232 | |||||||||
| Refseq | NM_001002231 (mRNA) NP_001002231 (protein) | NM_010645 (mRNA) NP_034775 (protein) | |||||||||
| Location | Chr 19: 56.07 - 56.08 Mb | Chr 7: 43.83 - 43.84 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Kallikrein-related peptidase 2, also known as KLK2, is a human gene.[1]
References
Further reading
- Riegman PH, Vlietstra RJ, van der Korput HA, et al. (1992). "Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species.". Mol. Cell. Endocrinol. 76 (1-3): 181-90. PMID 1726490.
- Qin H, Kemp J, Yip MY, et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization.". Hum. Hered. 41 (4): 222-6. PMID 1783409.
- Riegman PH, Vlietstra RJ, Klaassen P, et al. (1989). "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19.". FEBS Lett. 247 (1): 123-6. PMID 2468530.
- Schedlich LJ, Bennetts BH, Morris BJ (1988). "Primary structure of a human glandular kallikrein gene.". DNA 6 (5): 429-37. PMID 2824146.
- Frenette G, Deperthes D, Tremblay RR, et al. (1997). "Purification of enzymatically active kallikrein hK2 from human seminal plasma.". Biochim. Biophys. Acta 1334 (1): 109-15. PMID 9042371.
- Bourgeois L, Brillard-Bourdet M, Deperthes D, et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.". J. Biol. Chem. 272 (47): 29590-5. PMID 9368023.
- Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (1998). "Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors.". Prostate 34 (1): 44-50. PMID 9428387.
- Yu DC, Sakamoto GT, Henderson DR (1999). "Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy.". Cancer Res. 59 (7): 1498-504. PMID 10197620.
- Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (1999). "Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.". Int. J. Cancer 81 (3): 438-42. PMID 10209959.
- Lövgren J, Valtonen-André C, Marsal K, et al. (1999). "Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids.". J. Androl. 20 (3): 348-55. PMID 10386814.
- Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231-8. doi:10.1038/10290. PMID 10391209.
- Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors.". Eur. J. Biochem. 262 (3): 781-9. PMID 10411640.
- Mikolajczyk SD, Millar LS, Marker KM, et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue.". Cancer Res. 59 (16): 3927-30. PMID 10463585.
- Liu XF, Essand M, Vasmatzis G, et al. (1999). "Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.". Biochem. Biophys. Res. Commun. 264 (3): 833-9. doi:10.1006/bbrc.1999.1595. PMID 10544017.
- Ren F, Zhang S, Mitchell SH, et al. (2000). "Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells.". Oncogene 19 (15): 1924-32. doi:10.1038/sj.onc.1203511. PMID 10773882.
- Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.". J. Biol. Chem. 275 (48): 37397-406. doi:10.1074/jbc.M004525200. PMID 10969073.
- Chen VC, Chao L, Chao J (2001). "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein.". J. Biol. Chem. 275 (51): 40371-7. doi:10.1074/jbc.M005691200. PMID 10991942.
- Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119-30. PMID 11054574.
- Réhault S, Monget P, Mazerbourg S, et al. (2001). "Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.". Eur. J. Biochem. 268 (10): 2960-8. PMID 11358513.
- Saedi MS, Zhu Z, Marker K, et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells.". Int. J. Cancer 94 (4): 558-63. PMID 11745444.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
