KLK13
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| Kallikrein-related peptidase 13
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| Identifiers | ||||||||||||||
| Symbol(s) | KLK13; DKFZP586J1923; KLK-L4; KLKL4 | |||||||||||||
| External IDs | OMIM: 605505 MGI: 3615275 Homologene: 56714 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Image:PBB GE KLK13 217315 s at tn.png | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 26085 | 626834 | ||||||||||||
| Ensembl | ENSG00000167759 | ENSMUSG00000054046 | ||||||||||||
| Uniprot | Q9UKR3 | na | ||||||||||||
| Refseq | NM_015596 (mRNA) NP_056411 (protein) | XM_001001722 (mRNA) XP_001001722 (protein) | ||||||||||||
| Location | Chr 19: 56.25 - 56.26 Mb | Chr 7: 43.58 - 43.77 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Kallikrein-related peptidase 13, also known as KLK13, is a human gene.[1]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined.[1]
References
Further reading
- Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis.". Trends Endocrinol. Metab. 11 (2): 54-60. PMID 10675891.
- Yousef GM, Chang A, Diamandis EP (2000). "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues.". J. Biol. Chem. 275 (16): 11891-8. PMID 10766816.
- Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.". Biochem. Biophys. Res. Commun. 276 (1): 125-33. doi:10.1006/bbrc.2000.3448. PMID 11006094.
- Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119-30. PMID 11054574.
- Chang A, Yousef GM, Jung K, et al. (2002). "Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer.". Anticancer Res. 21 (5): 3147-52. PMID 11848466.
- Chang A, Yousef GM, Scorilas A, et al. (2002). "Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer.". Br. J. Cancer 86 (9): 1457-64. doi:10.1038/sj.bjc.6600283. PMID 11986781.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
- Petraki CD, Karavana VN, Diamandis EP (2003). "Human kallikrein 13 expression in normal tissues: an immunohistochemical study.". J. Histochem. Cytochem. 51 (4): 493-501. PMID 12642628.
- Komatsu N, Takata M, Otsuki N, et al. (2003). "Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages.". J. Invest. Dermatol. 121 (3): 542-9. doi:10.1046/j.1523-1747.2003.12363.x. PMID 12925213.
- Petraki CD, Gregorakis AK, Papanastasiou PA, et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.". Prostate Cancer Prostatic Dis. 6 (3): 223-7. doi:10.1038/sj.pcan.4500674. PMID 12970725.
- Kapadia C, Yousef GM, Mellati AA, et al. (2004). "Complex formation between human kallikrein 13 and serum protease inhibitors.". Clin. Chim. Acta 339 (1-2): 157-67. PMID 14687906.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
- Kapadia C, Ghosh MC, Grass L, Diamandis EP (2004). "Human kallikrein 13 involvement in extracellular matrix degradation.". Biochem. Biophys. Res. Commun. 323 (3): 1084-90. doi:10.1016/j.bbrc.2004.08.206. PMID 15381110.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
- (2006) "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005.". Biol. Chem. 387 (6): 635-824. doi:10.1515/BC.2006.081. PMID 16800723.
- Lundwall A, Band V, Blaber M, et al. (2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.". Biol. Chem. 387 (6): 637-41. doi:10.1515/BC.2006.082. PMID 16800724.
- Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP (2006). "Human kallikrein 13 expression in salivary gland tumors.". Int. J. Biol. Markers 21 (2): 106-10. PMID 16847813.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
