Jones oxidation
(Redirected from Jones reagent)
The Jones oxidation is a chemical reaction described as the chromic acid oxidation of primary and secondary alcohols to carboxylic acids and ketones, respectively.[1][2][3][4][5] Jones reagent - a solution of chromium trioxide in concentrated sulfuric acid - is used as the oxidizing agent
The solvent acetone markedly affects the properties of the chromic acid. The oxidation is very rapid, quite exothermic, and the yields are typically high. The reagent rarely oxidizes unsaturated bonds.
Unfortunately, the chromium residue is very toxic, and care must be taken to dispose of it properly.
References
- ↑ Bowden, K.; Heilbron, I. M.; Jones, E. R. H. J. Chem. Soc. 1946, 39.
- ↑ Heilbron, I.M.; Jones, E.R.H.; Sondheimer, F. J. Chem. Soc. 1949, 604.
- ↑ Bladon, P. et al. J. Chem. Soc. 1951, 2402.
- ↑ Jones, E. R. H. et al. J. Chem. Soc. 1953, 457 & 2548 & 3019.
- ↑ Djerassi, C. et al. J. Org. Chem. 1956, 21, 1547.
- Ley, S. V.; Madin, A. Comp. Org. Syn. 1991, 7, 253-256. (Review)
- Organic Syntheses, Coll. Vol. 5, p.310 (1973); Vol. 45, p.28 (1965). (Article)
- Organic Syntheses, Coll. Vol. 5, p.866 (1973); Vol. 45, p.77 (1965). (Article)
See also
Navigation WikiDoc | WikiPatient | Popular pages | Recently Edited Pages | Recently Added
Pictures
There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs
Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link HereThere is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
