John James Richard Macleod

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See also: John MacLeod

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Data 2:	September 6, 1876 Perth and Kinross, Scotland
Data 3 (data hidden if data3 empty or not defined):	March 16 1935 (aged 58) Scotland

John James Richard Macleod (September 6, 1876 – March 16, 1935) was a Scottish physician, physiologist, and recipient of the Nobel Prize in Physiology or Medicine.

Biography

Macleod was born at Clunie, Perth and Kinross, Scotland. He was the son of the Rev. Robert Macleod.

During 1898 he received his medical degree from University of Aberdeen and went to work for a year at the University of Leipzig. During 1899 he was appointed Demonstrator of Physiology at the London Hospital Medical School and in 1902 he was appointed Lecturer in Biochemistry at the school. During 1903 he was appointed Professor of Physiology at the Western Reserve University at Cleveland, Ohio. During 1918 he was elected Professor of Physiology at the University of Toronto, Canada.

Macleod's main work was on carbohydrate metabolism and his efforts with Frederick Banting and Charles Best in the discovery of insulin used to treat diabetes. For this Banting and Macleod were jointly awarded the Nobel Prize for Medicine in 1923. Macleod was awarded half of the Nobel Prize for the discovery of insulin, in spite of the fact that many people (including Banting) publicly insisted that Macleod's involvement was minimal and Best's work had been essential. However, it was MacCleod's research plan and his suggestion to inject intravenous degenerated pancreas into depancreatinized dog sugar that ultimately led to the successful isolation of insulin. There is currently a controversy regarding the role of Banting and Best in attempting to 'write out' Macleod and his colleague J.P. Collip from the history books. Macleod's receiving the Nobel Prize over Best was controversial at the time (see Nobel Prize controversies). He wrote eleven books, including Recent Advances in Physiology (1905); Diabetes: its Pathological Physiology (1925); and Carbohydrate Metabolism and Insulin. (1926)

The auditorium of the Medical Science Building at University of Toronto is named after J.J.R. Macleod. In 2005 Diabetes UK named its offices in London in honour of J.J.R. Macleod.

References

• Raju, Tonse N K (Oct 2006). "A mysterious something: the discovery of insulin and the 1923 Nobel Prize for Frederick G. Banting (1891-1941) and John J.R. Macleod (1876-1935)". Acta Paediatr. 95 (10): 1155-6. doi:10.1080/08035250600930328. PMID 16982482.
• Shampo, Marc A; Kyle Robert A (Aug 2006). "John J. R. Macleod--Nobel prize for discovery of insulin". Mayo Clin. Proc. 81 (8): 1006. PMID 16901021.
• Williams, M J (Jul 1993). "J. J. R. Macleod: the co-discoverer of insulin". Proceedings of the Royal College of Physicians of Edinburgh 23 (3): 1-125. PMID 11613051.
• Bliss, M (Mar 1989). "J. J. R. Macleod and the discovery of insulin". Quarterly journal of experimental physiology (Cambridge, England) 74 (2): 87-96. PMID 2657840.
• Hudson, R P (Aug 1979). "New light on the insulin controversey (Frederick G. Banting and J. J. R. Macleod)". Ann. Intern. Med. 91 (2): 311. PMID 380438.
• Kenéz, J (May 1970). "[Unknown chapters in the lore of insulin (in memory of J.J. Macleod)]". Orvosi hetilap 111 (18): 1050-3. PMID 4916661.
• ALLAN, F N (1955). "J.J.R. Macleod". Diabetes 4 (6): 491-2. PMID 13285390.

External links

• John Macleod – Biography
• John Macleod – Nobel Lecture, May 26, 1925

v • d • e Nobel Laureates in Physiology or Medicine
Emil Behring (1901) · Ronald Ross (1902) · Niels Finsen (1903) · Ivan Pavlov (1904) · Robert Koch (1905) · Camillo Golgi / Santiago Ramón y Cajal (1906) · Alphonse Laveran (1907) · Ilya Mechnikov / Paul Ehrlich (1908) · Emil Kocher (1909) · Albrecht Kossel (1910) · Allvar Gullstrand (1911) · Alexis Carrel (1912) · Charles Robert Richet (1913) · Robert Bárány (1914) · Jules Bordet (1919) · August Krogh (1920) · Archibald Hill / Otto Meyerhof (1922) · Frederick Banting / John Macleod (1923) · Willem Einthoven (1924)
Complete roster · 1901–1925 · 1926–1950 · 1951–1975 · 1976–2000 · 2001–present

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