Iodixanol
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| Image:Iodixanol-2D-skeletal.svg | |
| Iodixanol
| |
| Systematic (IUPAC) name | |
| 5 - [acetyl - [3 - [acetyl - [3,5-bis(2,3 - dihydroxypropylcarbamoyl) - 2,4,6 - triiodo - phenyl]amino] - 2 - hydroxy - propyl]amino] - N,N' - bis(2,3 - dihydroxypropyl) - 2,4,6 - triiodo - benzene - 1,3 - dicarboxamide | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C35H44I6N6O15 |
| Mol. mass | 1550.191 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | Negligible |
| Metabolism | Excreted unchanged |
| Half life | 2.1 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Iodixanol, is a contrast agent, sold under the trade name Visipaque®. Visipaque is commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. It is an iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H2O, the same as blood. It is sold in 2 main concentrations 270 mgI/ml and 320 mgI/ml - hence the name Visipaque 270 or 320. It is sold in single dose units and a large 500ml plastic bottle for multi-dose dispensing
It was originally made by Nycomed, which then merged with Amersham which finally was bought by Jeff Immelt to become GE Healthcare. The majority of Visipaque is made in Cork, Ireland, with additional plants in China and Oslo. All Iodixanol bulk powder is made in Norway and shipped to the various plants for final manufacture.
For gradient density centrifugation, the product is known as OptiPrep.
A very similar product also manufactured by GE Healthcare is Omnipaque (Iohexol as the main drug substance).
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External links
- [1]
- Iodixanol drug label/data at Daily Med from U.S. National Library of Medicine, National Institutes of Health.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
