Interleukin-27
| Interleukin 27
| |
| Identifiers | |
| Symbol | IL27 |
| Alt. Symbols | , IL30, p28 |
| Entrez | 246778 |
| HUGO | 19157 |
| OMIM | 608273 |
| RefSeq | NM_145659 |
| UniProt | Q6P676 |
| Other data | |
| Locus | Chr. 16 p11 |
| Interleukin 27B
| |
| Identifiers | |
| Symbol | IL27B |
| Alt. Symbols | EBI3 |
| HUGO | 3129 |
| OMIM | 605816 |
| UniProt | Q14213 |
| Other data | |
Overview
Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).[1] IL-27 is produced by antigen-presenting cells.[2] IL-27 plays an important function in regulating the activity of B and T lymphocytes.[3] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL-27R and gp130. The gene symbol IL27 refers to the IL-30 subunit of IL-27.[4]
References
- ↑ F. Larousserie et al., Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas Heterogeneous Expression of EBI3 Subunit by Tumoral Cells, American Journal of Pathology, 2005, Volume 166, pages 1217-1228.
- ↑ IL-27 regulates IL-12 responsiveness of naive CD4 [Proc Natl Acad Sci U S A. 2003] - PubMed Result
- ↑ F. Larousserie et al., Differential Effects of IL-27 on Human B Cell Subsets. Journal of Immunology, 2006, Volume 176, pages 5890-5897.
- ↑ http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157
Cytokines: interleukins | |
|---|---|
| IL-1 superfamily | IL-1 (IL-1Ra) - IL-18 - IL-33 |
| IL-6 like/gp130 utilizing | IL-6 - IL-11 - IL-27 - IL-30 - IL-31 |
| IL-10 family | IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26 |
| Interferon type III | IL-28 - IL-29 |
| Common γ-chain family | IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21 |
| IL-12 family | IL-12 - IL-23 - IL-27 - IL-35 |
| Other | IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32 |
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