Insulin-like growth factor binding protein

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The Insulin-like growth factor binding protein serves as a carrier protein for Insulin-like growth factor 1.

Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio.

IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. This is important because proliferating IGF-1 + IGF-BP complex allow growth of the femur and the muscle.

There are seven genes:

• IGFBP1
• IGFBP2
• IGFBP3
• IGFBP4
• IGFBP5
• IGFBP6
• IGFBP7

External links

• MeSH Insulin-like+growth+factor+binding+proteins

Template:Biochemistry-stub

v • d • e Proteins: carrier proteins
Hormone	Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin
Metal/element	calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor)
Vitamin	Retinol binding protein (4) - Transcobalamin
Other	Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein

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