Hurthle cells

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

Hurthle cells are also called Askanazy cells. They are the specific cells found in the thyroid gland and are visible on the histopathological picture. Hurthle cells have eosinophilic cytoplasm and are abundant in mitochondria. They may be present in a variety of thyroid diseases including Hashimoto's thyroiditis and thyroid carcinoma (Hürthle cel carcinoma; A subtype of follicular thyroid cancer).

Hurthle cells

Hurthle cells are also called Askanazy cells. They are the specific cells found in the thyroid gland and are visible on the histopathological picture. Hurthle cells have eosinophilic cytoplasm and are abundant in mitochondria. They may be present in a variety of thyroid diseases including Hashimoto's thyroiditis and thyroid carcinoma (Hürthle cel carcinoma; A subtype of follicular thyroid cancer).

History

The Hürthle cell is named after German histologist Karl Hürthle, who investigated thyroid secretory function, particularly in dogs. The cell known as the Hürthle cell was first described in 1898 by Max Askanazy, who noted it in patients with Graves' disease. Oncocytes in the thyroid are often called Hürthle cells. Although the terms oncocyte, oxyphilic cell, and Hürthle cell are used interchangeably, Hürthle cell is used only to indicate cells of thyroid follicular origin.

Microscopic Histology

Hurthle cells are also called Askanazy cells. They are the specific cells found in the thyroid gland and are visible on the histopathological picture. They may be present in a variety of thyroid diseases including Hashimoto's thyroiditis and thyroid carcinoma.
These cells are characterized by the following:

• Large, polygonal cells
• Eosinophilic cytoplasm
• Abundance of mitochondria

Micrograph of Hurthle cells; Courtesy of PathologyOutlines.com; Source:	Micrograph of Hurthle cell adenoma; Courtesy of Grace C. H. Yang, M.D and PathologyOutlines.com; Source:
Micrograph of Hurthle cell neoplasm, also known as oncocytic neoplasm; Source:By Nephron - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=9097925

Significance of Hurthle cells

Hurthle cells are present in the following conditions:

• Hashimoto's thyroiditis
• Grave's disease
• Benign thyroid adenomas
• Follicular thyroid carcinoma

Diagnosis

Hürthle cell adenomas are more frequent than Hürthle cell carcinomas. It is difficult to differentiate between being benign or malignant Hürthle cell lesions. Chronic lymphocytic thyroiditis or Hashimoto's thyroiditis, along with cases of long-standing Graves' disease, show Hürthle cells present. Classification is important since widely invasive tumors can have outcomes with a 55% mortality rate. Hürthle cell carcinomas consist of at least 75% Hürthle cells.

• Size and growth pattern of the tumor cannot be used to determine malignancy, although larger tumors have a higher incidence of malignancy, Hürthle cell adenomas and carcinomas are differentiated on the basis of capsular and vascular invasion.
• Tumors displaying only capsular invasion tend to behave less aggressively than those with vascular invasion.
• Hürthle cell carcinomas are characterized as either minimally invasive or widely invasive tumors.
• The minimally invasive or encapsulated carcinoma is fully surrounded by a fibrous capsule.
• The widely invasive carcinoma shows an extensive area of both capsular and vascular invasion with the leftover capsule typically difficult to identify.

Treatment

The appropriate diagnosis of the underlying cause of the Hurthle cells in the histological picture directs the treatment.

• Grave's disease and Hashimoto's thyroiditis are usually treated for hyperthyroidism and hypothyroidism respectively.
• A non-minimally invasive Hürthle cell carcinoma is typically treated by a total thyroidectomy followed by radioactive iodine therapy.
• A Hürthle cell adenoma or a minimally invasive tumor can be treated by a thyroid lobectomy, although some surgeons will perform a total thyroidectomy to prevent the tumor from reappearing and metastasizing.