Growth hormone releasing hexapeptide

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Growth hormone releasing hexapeptide
Image:GHRP-6.png
IUPAC name	L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide
Other names	GHRP-6
Identifiers
CAS number	87616-84-0
PubChem	5486806
MeSH	Growth+hormone+releasing+hexapeptide
SMILES	C[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CC=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CC6=CN=CN6)N
Properties
Molecular formula	C46H56N12O6
Molar mass	873.014
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Growth hormone releasing hexapeptide (GHRP6) is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids, were developed for their growth hormone (GH) releasing activity and are called GH secretagogues. They lack opioid activity but are potent stimulators of GH release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through action at a completely different receptor. This receptor was first called the GH secretagogue receptor, but now we know that the hormone ghrelin is this receptor's natural endogenous ligand and that these GH secetagouges act as synthetic mimetics of ghrelin.

References

• Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB (2004). "Ghrelin--a hormone with multiple functions". Frontiers in neuroendocrinology 25 (1): 27-68. doi:10.1016/j.yfrne.2004.03.002. PMID 15183037.