Cetrimonium bromide
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| Cetrimonium bromide | |
|---|---|
| |
| IUPAC name | hexadecyl-trimethyl-ammonium bromide |
| Identifiers | |
| CAS number | |
| PubChem | |
| SMILES | CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-] |
| Properties | |
| Molecular formula | C19H42BrN |
| Molar mass | 364.448 |
| Melting point |
237-243 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
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Cetrimonium bromide ((C16H33)N(CH3)3Br) is one of the components of the topical antiseptic cetrimide. The cetrimonium (or hexadecyltrimethylammmonium) cation is an effective antiseptic agent against bacteria and fungi.
It is a cationic surfactant. Its uses include providing a buffer solution for the extraction of DNA. It is also widely used in hair conditioning products.
As any surfactant, it forms micelles in aqueous solutions. At 303 K (30 °C) it forms micelles with aggregation number 75-120 (depending on method of determination, usually avg. ~95) and degree of ionization α (fractional charge) 0.2 - 0.1 (from low to high concentration).
Standard constant of Br- counterion binding to the micelle at 303 K (30 °C), calculated from Br- and CTA+ ion selective electrode measurements and conductometry data by using literature data for micelle size (r = ~3 nm), extrapolated to the critical micelle concentration is K° ≈ 400 (it varies with total surfactant concentration so it is extrapolated to the point at which the concentration of micelles is zero).
The closely related compounds cetrimonium chloride and cetrimonium stearate are also used as topic antiseptics, and may be found in many household products such as shampoos and cosmetics.
See also
References
- Merck Index, 11th Edition, 2019.
- Drug information
- Chemicalland21
- Household Products data base for cetrimonium chloride
- Household Products data base for cetrimonium bromide
cs:CTAB
de:Cetyltrimethylammoniumbromidid:Setiltrimetilamonium bromida
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
