Her 4
| v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
| |
| Identifiers | |
| Symbol | ERBB4 |
| Entrez | 2066 |
| HUGO | 3432 |
| OMIM | 600543 |
| RefSeq | NM_001042599 |
| UniProt | Q15303 |
| Other data | |
| Locus | Chr. 2 q34 |
Her-4, more commonly called ErbB4, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Like the epidermal growth factor receptor, Her-4 is able to bind to several activating ligands and dimerize with every other member of the EGFR family. Knock-outs of Her-4 in mice show developmental defects. However, Her-4 is thought to be expressed in low quantities, if at all, in most tissues, in contrast to the other Her receptors.
External links
Transmembrane receptor, tyrosine kinase: receptor tyrosine kinases (EC 2.7.10.1) | |
|---|---|
| I | EGF (HER2/neu, Her 3, Her 4) |
| II | Insulin - IGF-1 |
| III | Platelet-derived growth factor |
| IV | Fibroblast growth factor (FGFR1, FGFR2, FGFR3) |
| V | VEGF receptors - Flk-1 - Flt-1 |
| VII | TRK: TrkA - TrkB - TrkC |
| other | VIII: Eph (B2) - XI: Angiopoietin Receptors: Tie-1 & Tie-2 - XIV: RET - XVI: Related to receptor tyrosine kinase - XVII: MuSK |
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