Hematuria risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Steven C. Campbell, M.D., Ph.D. Adnan Ezici, M.D[2] Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [3]

Overview

Common risk factors in the development of hematuria include recent infection, strenuous exercise or normal exercise under extreme circumstances, males > 50 years old, and female sex (due to the higher prevalence of urinary tract infection). Common risk factors for urinary tract malignancy in patients with hematuria include age >35, analgesic abuse, exposure to chemicals or dyes (benzenes or aromatic amines), male sex, and smoking history.

Risk Factors

Common risk factors in the development of hematuria include:

  • Recent infection: Post-infectious glomerulonephritis, IgA nephropathy
  • Exercise: Long distance runners are prone to exercise-induced urinary bleeding.
  • Age: Males older than 50 years have an enlarged prostate that can cause hematuria.
  • Sex: 50% of all women suffer from urinary tract infections at least once in their lifetime, which can also cause urinary bleeding.
  • History of any of the following:
    • Chronic indwelling foreign body
    • Chronic urinary tract infection
    • Exposure to known carcinogenic agents or alkylating chemotherapeutic agents
    • Gross hematuria
    • Irritative voiding symptoms
    • Pelvic irradiation
    • Urologic disorder or disease

Common risk factors for urinary tract malignancy in patients with hematuria:[1][2][3]

  • Age older than 35 years
  • Analgesic abuse
  • Exposure to chemicals or dyes (benzenes or aromatic amines)
  • Male sex
  • Past or current smoking

History of any of the following:

  • Chronic indwelling foreign body
  • Chronic urinary tract infection
  • Exposure to known carcinogenic agents or alkylating chemotherapeutic agents
  • Gross hematuria
  • Irritative voiding symptoms
  • Pelvic irradiation
  • Urologic disorder or disease

References

  1. Sharp VJ, Barnes KT, Erickson BA (2013) Assessment of asymptomatic microscopic hematuria in adults. Am Fam Physician 88 (11):747-54. PMID: 24364522
  2. Richter LA, Lippmann QK, Jallad K, Lucas J, Yeung J, Dune T, Mellano E, Weissbart S, Mete M, Kim JH, Gutman R (2016). "Risk Factors for Microscopic Hematuria in Women". Female Pelvic Med Reconstr Surg. 22 (6): 486–490. doi:10.1097/SPV.0000000000000321. PMID 27636220.
  3. Jackson RE, Casanova NF, Wallner LP, Dunn RL, Hedgepeth RC, Faerber GJ, Wei JT (September 2013). "Risk factors for delayed hematuria following photoselective vaporization of the prostate". J. Urol. 190 (3): 903–8. doi:10.1016/j.juro.2013.03.070. PMID 23538242.