Hamartoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2] Vamsikrishna Gunnam M.B.B.S [3]

Overview

Hamartomas may be classified into different types based on their location, such as lung (most common), heart, hypothalamus, kidneys, or spleen. Other classification method considers lesion class, dividing hamartomas into 4 different categories, such as bone-forming, cartilage-forming, fiber-forming, and benign non–matrix-forming.

Classification

Location

Based on the location, hamartomas can be classified into the following types:

Location	Type
CNS	Hypothalamic hamartoma Neurofibromatosis in von Recklinghausen disease Neuroepithelial cells in tuberous sclerosis
Hypopharynx	Hypopharyngeal rhabdomyomatous
Eyelid	Rhabdomyomatous mesenchymal hamartoma
Lung	Endobronchial pulmonary hamartoma Parenchymal pulmonary hamartoma Bronchial hamartoma
Heart	Rhabdomyoma
Bowel	Peutz-Jeghers polyp Polyp of the large bowel
Kidneys	Angiomyolipoma
Spleen	Splenic hamartoma
Skin	Melanocytic nevi

Lesion class

Based on the lesion class, hamartomas may be classified into the following types:

Lesion class	Tumors type
Cartilage-forming	Enchondromatosis Epiphyseal osteochondroma Multiple osteochondroma Osteochondroma
Fiber-forming	Nonossifying fibroma Fibrous dysplasia
Bone-forming	Osteopathia striata Melorheostosis Osteopoikilosis Bone island
Benign non-matrix-forming	Skeletal hemangiomatosis Hemangioma of bone