Griffithsin

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Griffithsin, is a protein isolated from the red algae Griffithsia. It has a 121-amino acid sequence.^[1] It has been shown in vitro to be a highly potent HIV entry inhibitor. It is currently being investigated as a potential microbicide for use in the prevention of the transmission of HIV.^[2]

↑ Mori T, O'Keefe BR, Sowder RC, et al (2005). "Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp". J. Biol. Chem. 280 (10): 9345–53. doi:10.1074/jbc.M411122200. PMID 15613479.
↑ Emau P, Tian B, O'keefe BR, et al (2007). "Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide". J. Med. Primatol. 36 (4-5): 244–53. doi:10.1111/j.1600-0684.2007.00242.x. PMID 17669213.

[0] Mori T, O'Keefe BR, Sowder RC, et al (2005). "Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp". J. Biol. Chem. 280 (10): 9345–53. doi:10.1074/jbc.M411122200. PMID 15613479.

[1] Emau P, Tian B, O'keefe BR, et al (2007). "Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide". J. Med. Primatol. 36 (4-5): 244–53. doi:10.1111/j.1600-0684.2007.00242.x. PMID 17669213.

[1]

[2]

v • d • e Antivirals used against HIV (HAART) (primarily J05)
Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI)	Abacavir (ABC)° • Emtricitabine° • Lamivudine (3TC)° • Tenofovir° • Didanosine • Zidovudine (AZT) • Apricitabine^† • Stampidine^† • Elvucitabine^† • Racivir^† • Amdoxovir^† • Stavudine^‡ • Zalcitabine^‡
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)	Efavirenz° • Nevirapine • Etravirine • Rilpivirine^† • Loviride^‡ • Delavirdine^‡
Protease Inhibitors (PI)	Atazanavir° • Fosamprenavir° • Lopinavir° • Darunavir • Nelfinavir • Ritonavir • Saquinavir • Tipranavir • Amprenavir^‡ • Indinavir^‡
Entry/fusion inhibitors	Enfuvirtide • Maraviroc • Vicriviroc^† • PRO 140^† • Ibalizumab^†
Integrase inhibitors	Raltegravir • Elvitegravir^†
Maturation inhibitors	Bevirimat^† • Vivecon™^†
Combined formulations	Combivir • Atripla • Trizivir • Truvada • Kaletra • Epzicom
Other & experimental agents	Foscarnet • Hydroxyurea • Synergistic enhancers • Epigallocatechin gallate • Portmanteau inhibitors • Globoidnan A • Griffithsin • Diarylpyrimidines • Calanolide A • Cyanovirin-N • Miltefosine
°DHHS preferred first-line agent. ^†Undergoing clinical trials, not FDA approved. ^‡Formerly or rarely used agent.

Griffithsin

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WikiDoc Resources for Griffithsin
Most recent articles on Griffithsin Most cited articles on Griffithsin Review articles on Griffithsin Articles on Griffithsin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Griffithsin Images of Griffithsin Photos of Griffithsin Podcasts & MP3s on Griffithsin Videos on Griffithsin
Evidence Based Medicine
Cochrane Collaboration on Griffithsin Bandolier on Griffithsin TRIP on Griffithsin
Clinical Trials
Ongoing Trials on Griffithsin at Clinical Trials.gov Trial results on Griffithsin Clinical Trials on Griffithsin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Griffithsin NICE Guidance on Griffithsin NHS PRODIGY Guidance FDA on Griffithsin CDC on Griffithsin
Books
Books on Griffithsin
News
Griffithsin in the news Be alerted to news on Griffithsin News trends on Griffithsin
Commentary
Blogs on Griffithsin
Definitions
Definitions of Griffithsin
Patient Resources / Community
Patient resources on Griffithsin Discussion groups on Griffithsin Patient Handouts on Griffithsin Directions to Hospitals Treating Griffithsin Risk calculators and risk factors for Griffithsin
Healthcare Provider Resources
Symptoms of Griffithsin Causes & Risk Factors for Griffithsin Diagnostic studies for Griffithsin Treatment of Griffithsin
Continuing Medical Education (CME)
CME Programs on Griffithsin
International
Griffithsin en Espanol Griffithsin en Francais
Business
Griffithsin in the Marketplace Patents on Griffithsin
Experimental / Informatics
List of terms related to Griffithsin