Gliotoxin

Jump to navigation Jump to search

Template:Chembox new

WikiDoc Resources for Gliotoxin

Articles

Most recent articles on Gliotoxin

Most cited articles on Gliotoxin

Review articles on Gliotoxin

Articles on Gliotoxin in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Gliotoxin

Images of Gliotoxin

Photos of Gliotoxin

Podcasts & MP3s on Gliotoxin

Videos on Gliotoxin

Evidence Based Medicine

Cochrane Collaboration on Gliotoxin

Bandolier on Gliotoxin

TRIP on Gliotoxin

Clinical Trials

Ongoing Trials on Gliotoxin at Clinical Trials.gov

Trial results on Gliotoxin

Clinical Trials on Gliotoxin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Gliotoxin

NICE Guidance on Gliotoxin

NHS PRODIGY Guidance

FDA on Gliotoxin

CDC on Gliotoxin

Books

Books on Gliotoxin

News

Gliotoxin in the news

Be alerted to news on Gliotoxin

News trends on Gliotoxin

Commentary

Blogs on Gliotoxin

Definitions

Definitions of Gliotoxin

Patient Resources / Community

Patient resources on Gliotoxin

Discussion groups on Gliotoxin

Patient Handouts on Gliotoxin

Directions to Hospitals Treating Gliotoxin

Risk calculators and risk factors for Gliotoxin

Healthcare Provider Resources

Symptoms of Gliotoxin

Causes & Risk Factors for Gliotoxin

Diagnostic studies for Gliotoxin

Treatment of Gliotoxin

Continuing Medical Education (CME)

CME Programs on Gliotoxin

International

Gliotoxin en Espanol

Gliotoxin en Francais

Business

Gliotoxin in the Marketplace

Patents on Gliotoxin

Experimental / Informatics

List of terms related to Gliotoxin


Gliotoxin is a sulfur-containing antibiotic produced by some unrelated species of pathogenic fungi, such as Aspergillus, Trichoderma, and Penicillium, and by the yeast Candida. It was originally isolated from Gliocladium fimbriatum, and was named accordingly. It is an epipolythiodioxopiperazine metabilite.

Gliotoxin possesses immunosuppressive properties as it may suppress and cause apoptosis in certain types of cells of the immune system, including neutrophils, eosinophils, and granulocytes. Causes apoptosis in macrophages and thymocytes. It also acts as an inhibitor of farnesyl transferase. It noncompetitively inhibits the chymotrypsin-like activity of the 20S proteasome. In vivo it displays anti-inflammatory activity.[1] It acts by blocking thiol groups in the cell membranes.

References

  • Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro: A. Müllbacher, et al.; J. Gen. Microbiol. 131, 1251 (1985)
  • R.J. Jones & J.G. Hancock; J. Gen. Microbiol. 134, 2067 (1988) Gliotoxin stimulates Ca2+ release from intact rat liver mitochondria: M. Schweizer & C. Richter; Biochemistry 33, 13401 (1994)
  • Extracellular calcium is not required for gliotoxin or dexamethasone- induced DNA fragmentation: a reappraisal of the use of EGTA: P. Waring & A. Sjaarda; Int. J. Immunopharmacol. 17, 403 (1995)

External links

Gliotoxin product page from Fermentek


de:Gliotoxin

Template:WH Template:WikiDoc Sources