Foreign-body giant cell

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Histopathologic image of aspiration pneumonia in an elderly patient with debilitating neurologic illness. Note foreign-body giant cell reaction. Autopsy case. H & E stain.
Histopathologic image of aspiration pneumonia in an elderly patient with debilitating neurologic illness. Note foreign-body giant cell reaction. Autopsy case. H & E stain.

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Overview

A foreign-body giant cell is a collection of fused macrophages (giant cell) which are generated in response to the presence of a large foreign body. This is particularly evident with implants that cause the body chronic inflammation and foreign body response. [1]

The nuclei are arranged in a disorganized manner.[2] This is in contrast to a Langhans giant cell, where the nuclei are arranged on the border.

Additional images

Foreign-body giant cell reaction to a suture. H&E stain.

References

  1. ↑ MeSH Foreign+Body+Giant+Cell
  2. ↑ Inflammation.
v • d • e
Blood
GeneralPlasma – Hematopoietic stem cells
Lymphoid – WBCT cells: Cytotoxic CD8+, Helper CD4+/Regulatory, γδ, Natural Killer T cell

B cells: Plasma, Memory

Natural killer cells (Lymphokine-activated killer cell)

Null cell
Myeloid – WBCMonocytes/Macrophages (Histiocytes, Kupffer cells, Dust cell, Microglia, Osteoclasts, Epithelioid cells, Langhans giant cells, Foreign-body giant cell)

Granulocytes (Neutrophil, Eosinophil, Basophil) – Mast cell precursors

Dendritic cells (Langerhans cells, Follicular dendritic cells)

Megakaryoblast – Megakaryocyte – Platelets
Myeloid – RBCReticulocyte – Normoblast
v • d • e
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Articles on Foreign-body giant cellMost recent articles on Foreign-body giant cell • Most cited articles on Foreign-body giant cell • Review articles on Foreign-body giant cell • Articles on Foreign-body giant cell in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Foreign-body giant cellPowerpoint slides on Foreign-body giant cell • Images of Foreign-body giant cell • Photos of Foreign-body giant cell • Podcasts & MP3s on Foreign-body giant cell • Videos on Foreign-body giant cell
Evidence Based Medicine Regarding Foreign-body giant cellCochrane Collaboration on Foreign-body giant cell • Bandolier on Foreign-body giant cell • TRIP on Foreign-body giant cell
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Guidelines / Policies / Government Resources (FDA/CDC) Regarding Foreign-body giant cellUS National Guidelines Clearinghouse on Foreign-body giant cell • NICE Guidance on Foreign-body giant cell • NHS PRODIGY Guidance • FDA on Foreign-body giant cell • CDC on Foreign-body giant cell
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Patient Resources on Foreign-body giant cellPatient resources on Foreign-body giant cell • Discussion groups on Foreign-body giant cell • Patient Handouts on Foreign-body giant cell • Directions to Hospitals Treating Foreign-body giant cell • Risk calculators and risk factors for Foreign-body giant cell
Healthcare Provider Resources on Foreign-body giant cellSymptoms of Foreign-body giant cell • Causes & Risk Factors for Foreign-body giant cell • Diagnostic studies for Foreign-body giant cell • Treatment of Foreign-body giant cell
Continuing Medical Education (CME) Programs on Foreign-body giant cellCME Programs on Foreign-body giant cell
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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