Foreign-body giant cell

Histopathologic image of aspiration pneumonia in an elderly patient with debilitating neurologic illness. Note foreign-body giant cell reaction. Autopsy case. H & E stain.

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Overview

A foreign-body giant cell is a collection of fused macrophages (giant cell) which are generated in response to the presence of a large foreign body. This is particularly evident with implants that cause the body chronic inflammation and foreign body response.

The nuclei are arranged in a disorganized manner. This is in contrast to a Langhans giant cell, where the nuclei are arranged on the border.

Additional images

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  Foreign-body giant cell reaction to a suture. H&E stain.