Fertility medication

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Overview

Fertility medication may in a larger sense include any medication that enhances fertility, but in a specific sense consists of agents that stimulate follicle development of the ovary. It is a variant of assisted reproductive technology.

Agents that enhance ovarian activity can be classified as either Gonadotropin releasing hormone, Estrogen antagonists or Gonadotropins.

Gonadotropin releasing hormone

Main article: Gonadotropin-releasing hormone

Either Gonadotropin releasing hormone (GnRH) itself or any of its agonist may be used. GnRH releases gonadotropins from the hypothalamus in the body. GnRH agonists includes i.e. Lupron.

Estrogen antagonists

Fertility medication inhibiting the effects of estrogen includes Clomiphene citrate and Aromatase inhibitors.

Clomiphene citrate

Main article: Clomiphene citrate

Clomiphene citrate is a SERM. It inhibits the negative feedback of estrogen and therefore stimulates ovulation.

Aromatase inhibitors

Main article: Aromatase inhibitor

Although primarily a breast cancer treatment, aromatase inhibitors can also work as fertility medication, probably by a mechanism similar to clomiphene citrate.

Gonadotropins

Gonadotropins are the hormones in the body that normally stimulate the gonads (testes and ovaries). For medication, they can be extracted from urine or by genetic modification.

Menotropins

Main article: Menotropins

Menotropins are urinary gonadotropins, i.e. they are extracted from the urine.

Recombinant gonadotropins

Recombinant gonadotropins are gonadotropins created by inserting the DNA coding it into bacteriae. The bacterial DNA is then called Recombinant DNA. Examples of recombinant FSH are Follistim and Gonal F, while Luveris is a recombinant LH.

Human chorionic gonadotropin

Main article: Human chorionic gonadotropin#Use as medication

Human chorionic gonadotropin (hCG) is normally produced during pregnancy. However, it can also replace LH as a fertility medication.

Adverse effects

Estrogen antagonists and gonadotropins may stimulate multiple follicles and other ovarian hormones leading to multiple birth and possible ovarian hyperstimulation syndrome.

See also

Manufacturers:

• * Ferring Pharmaceuticals
• Organon International

EMD Serono

v • d • e Major Drug Groups
Gastrointestinal tract (A)	Antacids • Antiemetics  • H₂-receptor antagonists • Proton pump inhibitors • Laxatives • Antidiarrhoeals
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Skin (D)	Emollients - Antipruritics
Reproductive system (G)	Hormonal contraception • Fertility agents • Selective estrogen receptor modulators • Sex hormones
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Malignant and Immune disease (L)	Anticancer agents • Immunostimulators • Immunosuppressants
Muscles, Bones, and Joints (M)	Anabolic steroids • Anti-inflammatories • Antirheumatics • Corticosteroids • Muscle relaxants
Brain and Nervous system (N)	Anesthetics • Analgesics • Anticonvulsants • Mood stabilizers  • Anxiolytics • Antipsychotics • Antidepressants • Nervous system stimulants • Sedatives
Respiratory system (R)	Bronchodilators • Decongestants  • Antihistamines

fr:Liste de médicaments liés à la fertilité

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .