Familial mediterranean fever natural history, complications and prognosis

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Familial Mediterranean Fever Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Common complications of familial Mediterranean fever include amyloidosis and increased risk of vasculitic disorders. The prognosis does not differ from that of the general population. However, renal involvement is the determinant factor of patient survival rate.

Natural History, Complications, and Prognosis

Natural History

Complications

The most devastating complication of FMF is the development of AA-amyloidosis which may lead to end-stage renal disease.[4][5]

FMF may also be complicated with non-amyloid kidney disease such as:[6][7]

Other complications of FMF include:

Prognosis

References

  1. Sohar E, Gafni J, Pras M, Heller H (August 1967). "Familial Mediterranean fever. A survey of 470 cases and review of the literature". Am. J. Med. 43 (2): 227–53. PMID 5340644.
  2. Lidar M, Yaqubov M, Zaks N, Ben-Horin S, Langevitz P, Livneh A (June 2006). "The prodrome: a prominent yet overlooked pre-attack manifestation of familial Mediterranean fever". J. Rheumatol. 33 (6): 1089–92. PMID 16755655.
  3. Gafni J, Ravid M, Sohar E (1968). "The role of amyloidosis in familial mediterranean fever. A population study". Isr. J. Med. Sci. 4 (5): 995–9. PMID 5715490.
  4. 4.0 4.1 Akar S, Yuksel F, Tunca M, Soysal O, Solmaz D, Gerdan V, Celik A, Sen G, Onen F, Akkoc N (May 2012). "Familial Mediterranean fever: risk factors, causes of death, and prognosis in the colchicine era". Medicine (Baltimore). 91 (3): 131–6. doi:10.1097/MD.0b013e3182561a45. PMID 22543627.
  5. Lachmann, Helen J. (2015). "Long-Term Complications of Familial Mediterranean Fever". 3: 91–105. doi:10.1007/978-3-319-14615-7_6. ISSN 2282-6505.
  6. Kukuy O, Livneh A, Ben-David A, Kopolovic J, Volkov A, Shinar Y, Holtzman E, Dinour D, Ben-Zvi I (December 2013). "Familial Mediterranean fever (FMF) with proteinuria: clinical features, histology, predictors, and prognosis in a cohort of 25 patients". J. Rheumatol. 40 (12): 2083–7. doi:10.3899/jrheum.130520. PMID 24128782.
  7. Ardalan M, Nasri H (November 2014). "Massive proteinuria and acute glomerulonephritis picture in a patient with Familial Mediterranean fever and E148Q mutation". Iran J Kidney Dis. 8 (6): 486–8. PMID 25362225.
  8. Rigante, Donato; Federico, Gilda; Ferrara, Pietro; Maggiano, Nicola; Avallone, Laura; Pugliese, Anna Lisa; Stabile, Achille (2005). "IgA nephropathy in an Italian child with familial Mediterranean fever". Pediatric Nephrology. 20 (11): 1642–1644. doi:10.1007/s00467-005-2023-5. ISSN 0931-041X.
  9. Cagdas, Deniz N.; Gucer, Safak; Kale, Gülsev; Duzova, Ali; Ozen, Seza (2005). "Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature". Pediatric Nephrology. 20 (9): 1352–1354. doi:10.1007/s00467-005-1991-9. ISSN 0931-041X.
  10. Samli H, Içduygu FM, Ozgöz A, Akbulut G, Hekimler K, Imirzalioglu N (2009). "Surgery for acute abdomen and MEFV mutations in patients with FMF". Acta Reumatol Port. 34 (3): 520–4. PMID 19820675.
  11. Ciftci AO, Tanyel FC, Büyükpamukçu N, Hiçsönmez A (April 1995). "Adhesive small bowel obstruction caused by familial Mediterranean fever: the incidence and outcome". J. Pediatr. Surg. 30 (4): 577–9. PMID 7595838.
  12. Moradian, Mike M.; Sarkisian, Tamara; Amaryan, Gayane; Hayrapetyan, Hasmik; Yeghiazaryan, Anna; Davidian, Nairi; Avanesian, Nare (2013). "Patient management and the association of less common familial Mediterranean fever symptoms with other disorders". Genetics in Medicine. 16 (3): 258–263. doi:10.1038/gim.2013.112. ISSN 1098-3600.