Ewing's sarcoma differential diagnosis

Ewing's sarcoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.

Differentiating Ewing's Sarcoma from other Diseases

• Other entities that may have a similar radiologic presentation include
• Osteomyelitis
• Osteosarcoma (especially telangiectatic osteosarcoma): Ewing's sarcoma tends to arise from the diaphysis whereas in osteosarcoma it tends to arise from the metaphysis.
• Eosinophilic granuloma
• Malignant fibrous histiocytoma that erode into adjacent bone may also have a similar appearance.

Ewing's sarcomas are commonly found in the trunk and long bones. Therefore, they are commonly found in the pelvic region, clavicles, scapulas, vertebral column, and ribs. The most common bone for this to occur in is the femur, followed by the humerus and tibia. It should also be noted that Ewing's sarcoma has a strong potential to metastasize.