Endothelial stem cell
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Endothelial stem cells are multipotent stem cells. They are one of the three types of stem cells to be found in bone marrow.[1]
Endothelial stem cells' presence was demonstrated by Gerardo Rivera and Louis Gagné in 2005. Strong evidences for the presence of a heterogeneous population of endothelial progenitor cells (EPCs) in the sanguine circulation and in the endothelial population suggested the existence of endothelial stem cells. EPCs participate not only in maintaining the integrity and function of vascular endothelium but also in forming new blood vessels and they might play an important role in maintenance and regeneration of every organ of living organisms. Endothelial tissue is a dynamic structure in close contact with every organs of the body. The discovery of EPCs in tandem with emerging concepts in stem cell biology has generated interest and excitement in many fields such as medicine and tissue engineering.
The presence of endothelial CD34+ cells was observed in the aortic endothelial population. Their presence on treated polytetrafluoroethylene (PTFE or Teflon) proved that these cells could be isolated and used in-vitro. Stem cells characteristic spheroid structures were observed on PTFE surfaces enhancing endothelialisation. The surface of the PTFE films was treated with radiofrequency glow discharge ammonia plasma, conjugated with sulfosuccinimidyl 4-(N-maleidomethyl) cyclohexane-1-carboxylate (S-SMCC), and micropatterned with peptides sequences CGRGDS and CWQPPRARI, with the purpose of promoting the adhesion of bovine aortic endothelial cells (BAECs). Patterns were introduced with an aerosol micropatterning apparatus. Our results demonstrate the adhesion of BAECs on patterned PTFE that is to say we can promote endothelialisation of a synthetic surface with the new micropatterning technique and demonstrated the importance of endothelial stem cells during endothelialisation.
Our findings provide evidence suggesting that endothelial stem cells are present in the endothelium population. We are convinced that determining the promoter signaling of these endogenous endothelial stem cells will allow us to manipulate them with the objective of using them as future treatment in synthetic arterial prostheses and organogenesis.
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
